By: Joe Graedon June 18, 2026 35 Comments
    Will Zepbound or Wegovy Weight Loss Last?

    Unless you have been hiding in a cave, you have assuredly heard of GLP-1 agonists. Although these drugs were originally developed to help treat type 2 diabetes, they have made headlines because of the…

    By: Joe Graedon June 17, 2026 0 Comments
    The Ultimate Allergy Survival Guide: From Sneezi…

    For many people, allergies are little more than a nuisance—runny noses, itchy eyes and an occasional sneeze. But an Allergy Survival Guide becomes essential when allergies trigger asthma, severe s…

    By: Joe Graedon June 17, 2026 18 Comments
    Can GLP-1 Agonists Fix What Ails You — and War…

    Popular drugs approved for diabetes control and weight loss produce many other effects in the body as well. Drugs like semaglutide (Ozempic, Wegovy) have helped some people cut back on alcohol consump…

    By: Joe Graedon June 15, 2026 22 Comments
    Hormones and Breast Cancer: Why the Confusion Wo…

    For decades, women have been caught in the middle of one of medicine's most contentious debates. The question seems simple enough on the surface: does hormone replacement therapy (HRT) increase the ri…

    By: Joe Graedon June 14, 2026 9 Comments
    Are You Taking A Sleeping Pill That Messes with …

    Sleeping pills are big business. That is especially true for over-the-counter drugs. Millions of people take “PM” pain relievers regularly because they fear they may not fall asleep easily. Diphen…

    By: Joe Graedon June 11, 2026 48 Comments
    Hidden Memories in Alzheimer’s Disease: Do…

    For generations, families have watched loved ones disappear into the fog of Alzheimer's disease. As memory fades and communication becomes challenging, many assume that the person they once knew and l…

    By: Joe Graedon June 8, 2026 3 Comments
    How Well Does Ritalin Work for ADHD?

    For decades the stimulant drug Ritalin has been a mainstay in the treatment of attention deficit hyperactivity disorder, or ADHD. It is also sold under the generic name methylphenidate and brand names…

    By: Joe Graedon June 8, 2026 7 Comments
    Are There Alternatives to an EpiPen? neffy? Prim…

    Several years ago, there was quite a fuss about high prices and shortages affecting EpiPen emergency allergy injections. This epinephrine shot is used to avert anaphylactic shock that can be life thre…

    By: Joe Graedon June 8, 2026 42 Comments
    The Pros and Cons of Topical NSAIDs Like Voltare…

    When the FDA allowed drug companies to sell NSAIDs over the counter we were concerned. That's because drugs like ibuprofen (Advil, Motrin IB, etc) and naproxen (Aleve) came with some pretty serious si…

    By: Joe Graedon June 8, 2026 21 Comments
    Dangers of Antidepressants: Life Savers or Hidde…

    Americans are taking antidepressant medications in huge numbers and the trend is upward. The most recent data show that: "Overall, antidepressant use increased from 9.8% in 2019 to 11.4% in 2023" (Cur…

    By: Suzanne Robotti June 4, 2026 3 Comments
    Pediatrics–What Are You Thinking about Generic…

    by Suzanne Robotti, MedShadow Foundation The American Academy of Pediatrics (AAP) released a policy statement this week on the bioequivalency of generic drugs to brand name drugs. Their conclusion sta…

    By: Joe Graedon June 1, 2026 4 Comments
    New Ways to Stop Nosebleeds

    More than twenty years ago, we got our first letter about using cold car keys against the back of the neck to stop nosebleeds. As you will see, we thought it was a bit bizarre. Keys to Stop Nosebleeds…

    By: Joe Graedon June 1, 2026 55 Comments
    Hydrochlorothiazide (HCTZ) Side Effects, Diabete…

    We suspect that hydrochlorothiazide (HCTZ or HCT for short) is one of the most prescribed drugs in America on a daily basis. HCTZ is taken regularly by over 15 million people. Many doctors believe tha…

    By: Terry Graedon June 1, 2026 43 Comments
    Suffering Side Effects from Mirapex for Restless…

    Restless legs syndrome, or RLS, doesn't sound like a serious health condition. (Maybe that's why doctors and researchers sometimes call it Willis-Ekbom disease.) This neurological condition results in…

    By: Joe Graedon May 28, 2026 10 Comments
    Does Your Medicine Have a Boxed Warning? Why You…

    When people are poised to participate in risky activities, they are supposed to follow safety protocols. For example, sky divers exercise proper precautions and procedures before each jump. No commerc…

    By: Dennis Miller, RPh May 28, 2026 10 Comments
    When Doctors Prescribe and Patients Push Back

    Dennis Miller, R.Ph. is a retired chain store pharmacist. His book, The Shocking Truth About Pharmacy: A Pharmacist Reveals All the Disturbing Secrets, can be downloaded in its entirety at Amazon for …

    By: Joe Graedon May 27, 2026 60 Comments
    Do Treatments for Knee Arthritis Do More Harm Th…

    Steroid shots and arthroscopic surgery have been mainstays in the treatment of pain and inflammation brought on by knee arthritis. Many people try to delay knee replacement as long as possible, especi…

    By: Joe Graedon May 25, 2026 27 Comments
    Do Heartburn Drugs or Antihistamines Trigger RLS…

    What causes Restless Legs Syndrome (RLS)? Check with most medical authorities and you will learn that “there’s no known cause” (Mayo Clinic). Symptoms are often blamed on a chemical imbalance in…

    By: Terry Graedon May 24, 2026 14 Comments
    Can Aspirin Help Prevent Sunburn? Surprising Sci…

    It's that time of year when people start stocking up on sunscreen. Whether it's gardening, a trip to the beach, a picnic in the backyard or a game of golf, sunscreen, protective clothing and a good ha…

    By: Joe Graedon May 21, 2026 27 Comments
    When Blood Pressure Treatment Raises the Risk of…

    For decades, doctors have emphasized the importance of lowering blood pressure to prevent heart attacks and strokes. With good reason! The CDC estimates that: "More than 843,000 Americans die of heart…

    By: Joe Graedon May 21, 2026 15 Comments
    Will FDA Fumbles and Firings, Chaos and Cutbacks…

    The Food and Drug Administration is in the middle of a meltdown. I do not recall so many high-level departures in such a short time in the middle of a presidential term. Many readers of this newslette…

    By: Terry Graedon May 18, 2026 34 Comments
    Is There a Downside to Ashwagandha?

    Have you been looking for natural ways to get some sleep? That is certainly understandable. When you are worrying about family members and friends, you may not be able to sleep well. Some herbs could …

    By: Joe Graedon May 18, 2026 44 Comments
    Hormone Therapy for Bones and Libido: Osteoporos…

    For decades, hormone replacement therapy (HRT) has been controversial, caught between fear and renewed enthusiasm. Now, a growing number of women are asking a different question: could Hormone Therapy…

    By: Joe Graedon May 18, 2026 27 Comments
    When Doctors Prescribe Ozempic for Weight Loss

    If you have been reading our newsletter, you know that semaglutide is one of the hottest medications in the pharmacy. For months, this self-injected diabetes drug was "Currently in Shortage." Why woul…

    By: Terry Graedon May 18, 2026 26 Comments
    How to Get Rid of a Wart with Tagamet (Cimetidin…

    Warts can affect almost anyone. For reasons that are not clear, children seem especially susceptible. In theory, their immune systems are working well, so they should be more resistant to viral infect…

    By: Joe Graedon May 13, 2026 28 Comments
    Dr. Marty Makary Couldn’t Heal the FDA–Now H…

    On November 28, 2024, I was pleased to announce that: “President-elect Trump has nominated a Johns Hopkins surgeon, Dr. Martin Makary, to lead the Food and Drug Administration. Can he create a new e…

    By: Terry Graedon May 11, 2026 17 Comments
    Will You Get Osteoporosis If You Take Omeprazole…

    Do you take omeprazole (Prilosec) or another proton pump inhibitor such as esomeprazole (Nexium) or lansoprazole (Prevacid)? Such PPI drugs were once thought to be relatively free of side effects, but…

    By: Terry Graedon May 6, 2026 18 Comments
    Will Ozempic Lead to Hair Loss?

    Over the past several years, the FDA has approved a number of medications designed to help people with type 2 diabetes control their blood sugar. You may have seen some of them advertised on televisio…

    By: Terry Graedon May 5, 2026 7 Comments
    How Slick Marketing Attempts to Humanize Pharmac…

    Dennis Miller, R.Ph. is a retired chain store pharmacist. His book, The Shocking Truth About Pharmacy: A Pharmacist Reveals All the Disturbing Secrets, can be downloaded in its entirety at Amazon for …

    By: Joe Graedon May 4, 2026 4 Comments
    Nicotine for Brain Power: Promise, Peril or Plac…

    Americans are always searching for ways to stay sharp, focused and mentally competent. There is nothing worse for an older person who is searching for a word than to have to apologize by resorting to …

    By: Joe Graedon May 4, 2026 413 Comments
    Amlodipine (Norvasc) Side Effects Include Swolle…

    For reasons that remain somewhat mysterious to us, amlodipine (Norvasc) is one of the most popular blood pressure medications in the pharmacy. This calcium channel blocker lowers blood pressure in par…

    By: Joe Graedon May 4, 2026 60 Comments
    Why Buproprion Smells Bad: Uncovering the Myster…

    Some drugs have a distinctive odor. That’s a nice way of saying that some medications naturally smell nasty. For example, Mucomyst (acetylcysteine) is prescribed to dissolve mucus. It can smell like…

    By: Joe Graedon May 4, 2026 18 Comments
    Are GLP-1 Weight Loss Drugs Stealing Muscle Stre…

    GLP-1 agonists have been hailed as miracle drugs. Medications like semaglutide and tirzepatide are transforming the treatment of obesity, helping people lose weight when nothing else seemed to work. W…

    By: Terry Graedon April 30, 2026 13 Comments
    Is Thyroid Treatment Linked to Osteoporosis?

    Doctors have long known that people who make too much thyroid hormone are at risk for weakened bones. This is also a problem for those who take synthetic levothyroxine to supplement their underactive …

    By: Joe Graedon April 27, 2026 7 Comments
    Drug Effectiveness: The Missing Number Behind Ev…

    You might assume that drug effectiveness would be one of the most important things a doctor would discuss when writing a new prescription. That almost never happens. Patients may be told what a medici…

    By: Terry Graedon April 27, 2026 29 Comments
    How Can You Counteract Muscle Pain from Statins?

    The doctors' debate over statins has become heated. You can read what we have written about that here and here. If you prefer, you can listen to our interviews with leading cardiologists here. But pat…

    By: Joe Graedon April 27, 2026 16 Comments
    How to Soothe Allergy Symptoms Without Serious S…

    Allergy season takes a terrible toll on people who are susceptible to pollen. This is the time of year when invisible particles in the air trigger sneezing, sniffling, itching and congestion. Allergy …

    By: Joe Graedon April 27, 2026 10 Comments
    Pills or Shots for Obesity? New Foundayo Pills v…

    The FDA approved oral Wegovy (semaglutide) on December 22, 2025. Eli Lilly received approval for its pill, Foundayo (orforglipron), on April 1, 2026. It will be a fight for America’s fat. Instead of…

    By: Joe Graedon April 20, 2026 30 Comments
    The Informed Consent Charade: Are Patients Truly…

    Before any surgery or medical treatment, patients are asked to agree to what is known as informed consent. What does that mean? Health care providers have both a legal and an ethical responsibility t…

    By: Joe Graedon April 20, 2026 14 Comments
    Will Nexletol (Bempedoic Acid) Replace Statins?

    Statins overwhelmingly dominate pharmacy sales. At last count, over 50 million people take statin-type cholesterol-lowering drugs such as atorvastatin, rosuvastatin and and simvastatin. That does not …