By: Terry Graedon January 20, 2022 1 Comments
    Show 1287: Managing Stress and Anxiety During CO…

    The COVID-19 pandemic has been dragging on for longer than most people imagined possible. With each new variant, cases surge and people need to make complex risk calculations about school, work and so…

    By: Joe Graedon January 10, 2022 4 Comments
    Can You Deal with Depression and Manage Anxiety?

    For more than two years now, all of us have had to deal with major disruptions in our lives. Coronavirus changed the way we live almost overnight. What's more, every time we've thought it might be com…

    By: Joe Graedon January 3, 2022 248 Comments
    How To Stop Duloxetine (Cymbalta) Without Withdr…

    Based on what we hear from readers of our syndicated newspaper column and visitors to this website, most patients are not warned about how to stop duloxetine (Cymbalta). Perhaps the prescriber assumes…

    By: Joe Graedon December 20, 2021 4 Comments
    Beware of Serotonin Syndrome from Cough Remedy I…

    Chances are good that you’ve heard of serotonin. It is a neurotransmitter in the brain that has been linked to mood. Fluoxetine (Prozac) and its antidepressant chemical cousins (citalopram or Celexa…

    By: Joe Graedon November 18, 2021 26 Comments
    Long Covid Is Common and Scary!

    Some people continue to maintain that COVID-19 is no big deal. With over 47 million cases confirmed in the US and more than 768,000 deaths, this disease is a very big deal. Global deaths from COVID ha…

    By: Terry Graedon October 14, 2021 1 Comments
    Diet with Mushrooms May Protect You from Depress…

    Mushroom lovers, rejoice! A diet with mushrooms appears to offer you a lower risk of developing depression and other mental illness. Advantages of a Diet with Mushrooms: Penn State scientists evaluate…

    By: Terry Graedon October 7, 2021 22 Comments
    Are You Suffering Senility or Vitamin B12 Defici…

    Whether they admit it or not, a lot of middle-aged and older people worry about senility. By this, they mean cognitive difficulties or even dementia, perhaps coupled with physical frailty. However, ge…

    By: Terry Graedon September 30, 2021 0 Comments
    Eating Fruits and Veggies Boosts Children’…

    A study published in BMJ Nutrition, Prevention & Health analyzed the impact of nutritional factors on mental wellbeing in kids (BMJ Nutrition, Prevention & Health, Sept. 27, 2021). The researc…

    By: Terry Graedon September 9, 2021 3 Comments
    Show 1271: New Approaches to Managing Depression

    For many months now, people have been dealing with the pandemic, Which has brought both grief for the lives lost and anxiety about the threat of infection. At the same time, fires and floods have made…

    By: Terry Graedon August 9, 2021 0 Comments
    Do Lonely Older People Take More and Riskier Dru…

    Doctors write a lot of prescriptions for anti-anxiety agents, pain medicine, sleeping pills and antidepressants. The last time we checked, 22 million Americans were filling more than 100 million presc…

    By: Joe Graedon June 21, 2021 174 Comments
    Problems with Generic Wellbutrin (Bupropion)? No…

    More than a decade ago we received a message from J. in Danville, New York about her antidepressant--generic Wellbutrin (bupropion). She said: "I have been taking Budeprion XL 300 mg for three months …

    By: Terry Graedon June 3, 2021 4 Comments
    Show 1260: The Pros and Cons of Online Therapy D…

    Last year, just when more people than ever needed the help of a therapist, stay-at-home restrictions made it difficult or impossible to get face-to-face counseling. Moreover, most therapists were comp…

    By: Joe Graedon May 24, 2021 20 Comments
    High Cost of Spravato (Esketamine) For Depressio…

    The first really new antidepressant in decades won FDA approval for treatment-resistant depression in March, 2019. Esketamine nasal spray is sold under the brand name Spravato. Physicians and patients…

    By: Terry Graedon April 15, 2021 6 Comments
    Psilocybin from Mushrooms Can Ease Depression

    Psilocybin is the psychoactive compound in hallucinogenic mushrooms. Humans have used this magic mushroom compound in rituals for thousands of years. The compound alters sensory perceptions and even t…

    By: Terry Graedon February 25, 2021 1 Comments
    Show 1248: How to Keep Moving and Feel Better Du…

    COVID-19 restrictions have interfered with the way many of us exercise. Yet the benefits of moving, for both our physical and mental health, are more important than ever. How can we keep moving to fee…

    By: Joe Graedon January 25, 2021 0 Comments
    Lithium Damages Kidneys While Helping Bipolar Di…

    I worked in the Neuropharmacology Laboratory at the New Jersey Neuropsychiatric Institute between 1967 and 1969. The head of our lab was Carl Pfeiffer, MD, PhD. He was considered the father of orthomo…

    By: Joe Graedon December 28, 2020 4 Comments
    Bad Mix? Diphenhydramine – Benadryl and SSRI A…

    There are two kinds of drugs that are taken by tens of millions of people. One is an antihistamine called diphenhydramine (Benadryl). It is highly sedating, which is why many people don’t like to ta…

    By: Terry Graedon December 3, 2020 1 Comments
    Show 1238: How Is COVID-19 Affecting Mental Heal…

    These are stressful times. Many people are grieving the death of a loved one, while others are struggling with working or studying from home. Being separated from loved ones can be emotionally drainin…

    By: Terry Graedon November 26, 2020 4 Comments
    Show 1237: Improving Your Mood With Food

    Working from home during the pandemic has wrought havoc with a lot of healthy eating habits. It’s harder to shop safely, and minimizing time in the grocery store may mean people have stocked up on s…

    By: Terry Graedon October 15, 2020 9 Comments
    How Your Home Address Affects Your Health

    Where people live can have a profound impact on their risk of developing certain chronic health conditions. Scientists have been able to map the differences in health conditions across the United Stat…

    By: Joe Graedon June 15, 2020 13 Comments
    When a Drug Like Buproprion Smells Bad

    Some drugs have a distinctive odor. That’s a nice way of saying that some medications naturally smell nasty. For example, we have seen complaints that the blood pressure medicine diltiazem has a str…

    By: Joe Graedon May 7, 2020 6 Comments
    Antidepressants and Thoughts of Suicide – Were…

    We are living through some really rough times. Even before the coronavirus pandemic, tens of millions of Americans were anxious or depressed. We can hardly begin to imagine how many people are in dist…

    By: Terry Graedon April 23, 2020 1 Comments
    COVID-19 Is Making People Anxious and Depressed

    Not surprisingly, the pandemic that has many people trapped in their homes and others putting their lives on the line as they do essential work has affected mental health as well as physical health. C…

    By: Terry Graedon March 12, 2020 1 Comments
    Show 1204: How Brain Function Affects Mental Ill…

    Mental health problems cause widespread disability in today’s world. Large numbers of people suffer with depression or severe anxiety. While these ailments are real, we may not be considering their …

    By: Joe Graedon February 10, 2020 5 Comments
    Wellbutrin XL Antidepressant Is Affordable in Ca…

    Several years ago we shook up the Food and Drug Administration when we complained about a generic form of the Wellbutrin XL antidepressant. We had received hundreds of complaints about a branded gener…

    By: Joe Graedon January 30, 2020 9 Comments
    Can Lithium in Water Supply Prevent Dementia?

    The chances are good that you are exposed to some lithium almost every day of your life. That's because this natural element is plentiful in nature. It is found in rocks and soil all over the earth. T…

    By: Terry Graedon January 30, 2020 6 Comments
    Do Psychological Benefits from Psilocybin Last?

    Several years ago, scientists at New York University Langone Medical Center and Johns Hopkins University reported on an extraordinary pilot study. Both research groups reported that cancer patients co…

    By: Joe Graedon December 26, 2019 9 Comments
    Is Your Doctor Stressed? Depressed Doctors Are D…

    Most patients have no way of assessing the mental state of their physician, but it could have a significant impact on safety. A systematic review published in JAMA Network Open (Nov. 27, 2019) analyze…

    By: Joe Graedon December 2, 2019 3 Comments
    Losartan and Suicide: Is This a Real Side Effect…

    Depression can occur for many reasons. Losing a job can create anxiety and sometimes depression. Divorce or the death of a loved one can also send you into a tailspin. A surprisingly large number of m…

    By: Terry Graedon November 7, 2019 5 Comments
    Show 1188: The Healing Potential of Psychedelic …

    Many indigenous peoples around the world have developed traditional uses for psychedelic compounds. In Western medicine, these were mostly unknown until Albert Hoffmann synthesized LSD (lysergic acid …

    By: Terry Graedon November 7, 2019 0 Comments
    Can You Fight Depression by Eating the Mediterra…

    Epidemiologists have long known that people who eat a lot of junk food are more vulnerable to depression. Australian researchers have just conducted a study to see whether improving diet also improves…

    By: Joe Graedon October 31, 2019 11 Comments
    Is Therapy Better Than Drugs for Depression?

    Americans are depressed. According to our calculations, roughly 40 million people are taking antidepressant medications. The CDC concludes that’s 12.7% of people over 12 years of age (NCHS Data Brie…

    By: Terry Graedon October 31, 2019 2 Comments
    What Other Drugs Boost Antidepressants’ Ef…

    For years, psychiatrists have been wondering how to improve antidepressants' effectiveness. People with depression are usually treated with medications such as desvenlafaxine (Pristiq), escitalopram (…

    By: Joe Graedon October 21, 2019 8 Comments
    Stop-Smoking Drug Chantix Triggers Violence

    Most Americans find it hard to believe that a medication could change someone's personality. The idea that a person could actually harm another human as a result of a drug side effect seems prepostero…

    By: Terry Graedon September 26, 2019 4 Comments
    Show 1182: How You Can Use Exercise as Medicine

    Does medicine mean “drugs and surgery” to you? That is certainly how a lot of people see it. However, physical activity–exercise–has powerful abilities to help us heal. How can we use exercise…

    By: Terry Graedon September 12, 2019 6 Comments
    Show 1180: How to Eat to Nourish Your Brain

    You know your body needs food to fuel it. You’ve probably thought about whether you should be eating more fat or less, how much protein you might need and if you are getting enough vegetables and fr…

    By: Terry Graedon September 2, 2019 2 Comments
    Is Depression Linked to Metformin for Diabetes?

    Doctors and patients both may have a hard time determining when a new health concern is actually a side effect. That's especially difficult when you don't find the problem on any official list of drug…

    By: Terry Graedon August 19, 2019 3 Comments
    Can You Overcome Trouble with Generic Antidepres…

    Have you ever had trouble with generic antidepressants? We have heard from many readers who report difficulties in switching from brand-name to generic or between different generic medications. I…

    By: Joe Graedon August 12, 2019 5 Comments
    Ketamine for Surgery Lifts Cloud of Depression

    Sometimes patients discover a new use for an old drug on their own. It’s what we call serendipity. Lexico.com defines serendipity as: “The occurrence and development of events by chance in a happy…

    By: Terry Graedon August 1, 2019 1 Comments
    Can Resveratrol Help Ease Stress, Anxiety and De…

    Scientists have been investigating resveratrol, a compound found in grapes, berries, peanuts, cacao beans, knotweed and many other plants for about four decades. They have discovered that this polyphe…