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The fascinating compound called metformin was discovered nearly a century ago. Scientists realized that it could lower blood sugar in an animal model (rabbits) as early as 1929, but it wasn’t until the late 1950s that a French researcher came up with the name Glucophage (roughly translated as glucose or sugar eater). The FDA gave metformin (Glucophage) the green light for the treatment of type 2 diabetes in 1994, 36 years after it had been approved for this use in Britain. Now researchers are discovering that metformin has anti-cancer activity, especially in men with prostate cancer (Canadian Journal of Urology, Oct. 2018). But GI side effects are common.
Uses of Generic Metformin (Glucophage):
Glucophage lost its patent protection in the U.S. in 2002 and now most prescriptions are filled with generic metformin. Doctors recognize this drug as a first line treatment to control blood sugar by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes. Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control (Current Obesity Reports, June 2019).
Starting early in 2000, a new class of diabetes drugs started to compete with sales of metformin (Glucophage). First Avandia and then Actos challenged metformin for leadership in diabetes treatment. Avandia later lost its luster because it was linked to heart attacks and strokes. Sales of this drug are now miniscule because of tight FDA regulations.
Actos came under increased scrutiny as well. The drug has been banned in France and Germany because of a link to bladder cancer. The FDA has also required Actos to carry its strictest black box warning about an increased risk of congestive heart failure brought on by the drug. Newer diabetes drugs like liraglutide (Victoza), saxagliptin (Onglyza) and sitagliptin (Januvia) have become very successful. Nonetheless, metformin remains a mainstay of diabetes treatment. Healthcare professionals prescribe metformin on its own or sometimes combined with the newer diabetes drugs.
Metformin (Glucophage) as First-Line Treatment for Type 2 Diabetes:
This all means that metformin has regained its reputation as the best bang for the buck when it comes to type 2 diabetes management. The American College of Physicians has recommended metformin as the first line of treatment when lifestyle changes (diet, exercise and weight loss) have not led to adequate blood glucose control.
That may be why more than 17 million people take this drug daily. Roughly 90 million metformin prescriptions are dispensed annually. Despite a large number of new medications for type 2 diabetes, metformin still seems to offer the best value.
Despite all the warm, fuzzy feelings about using this medication for type 2 diabetes, there are some caveats. This drug may cause a number of side effects, especially when it comes to the gastrointestinal tract. They can be especially bothersome during the first few weeks of treatment. After several weeks, however, the digestive symptoms often fade away. If they recur, notify your doctor immediately as they could be symptoms of lactic acidosis (see below). Here is a list of adverse reactions to watch out for:
Metformin Side Effects:
- Heartburn
- Stomach ache
- Diarrhea
- Gas
- Headache
- Nausea
- Loss of appetite
- Weakness
- Rash
- Lactic acidosis (symptoms may include irregular heart rate, nausea, stomach pain, lethargy, anxiety, low blood pressure and rapid heart rate) Notify your physician immediately if you notice any of these symptoms!
These side effects may seem daunting, but most people tolerate this medication quite well. The drug can be dangerous for people with kidney disease, however. They should not take the drug, and everyone on metformin should have their kidney function monitored regularly (at least once a year). People with congestive heart failure should not take metformin either.
A Patient’s Experience with Metformin and Bathroom Emergencies:
Q. I was on metformin for years with no problem. Then my dose was increased, and I started to have colon spasms and extreme bathroom urgency.
The doctor prescribed meds to manage that, but this wasn’t perfect. I started to stay home and skip a lot of activities.
My physician took me off metformin and the GI drugs, and now I’m fine. It’s much better not to worry about bathroom emergencies.
A. Digestive problems including diarrhea are not uncommon with metformin. The extended release formulation seems less likely to cause this problem. In addition, taking metformin with a meal may help.
Diarrhea and kidney damage from metformin?
Q. Metformin was my lifesaving med for years, until suddenly it wasn’t! After ten years of constant diarrhea (which I hated) and weight loss (which I loved), I was diagnosed with stage 3 kidney failure and IBS.
Now I struggle to keep my type 2 diabetes under control with low-carb foods plus cinnamon tabs. My HbA1c is not great at 6.9, but not disastrous.
While metformin can be a super drug for some people, it can be a very dangerous drug for others.
A. Metformin remains the most prescribed drug for type 2 diabetes in the world. French regulators approved it in 1957, while the FDA waited until 1994 to make it available in the US.
Although metformin helps control blood sugar and has both anti-inflammatory and anti-cancer activity, it does have some serious side effects. In addition to digestive distress, some people suffer from headache, liver damage and lactic acidosis. This metabolic condition can be life threatening. Symptoms include rapid pulse, palpitations, low blood pressure, lethargy and severe stomach pain. People with poor kidney function are more vulnerable to this complication and should probably not take metformin.
Another reader complains about awful GI side effects:
Q. You have written about metformin to control blood sugar, but you didn’t cover my experience. For over a year, I suffered through horrendous bouts of vomiting and diarrhea, sometimes as often as once per week. My PCP sent me for tests, including a colonoscopy and ultrasound. We found nothing to explain it.
During my latest visit, she told me to begin taking a probiotic and to stop taking metformin. That was early spring and I haven’t had a bout of vomiting and diarrhea since! I wanted to share this with your readers.
A. As we’ve noted, providers prescribe metformin more commonly than any other medicine for type 2 diabetes. The most frequent side effects involve the digestive tract. They include heartburn, nausea, stomachache, diarrhea, gas and loss of appetite.
The most serious complication is a buildup of lactic acid. Symptoms such as rapid or irregular heart rate, abdominal pain, fatigue, nausea and low blood pressure could signal this condition.
To learn more about other ways to manage blood sugar, you may wish to consult our eGuide to Preventing and Treating Diabetes. This online resource is available under the Health eGuides tab.
Vitamin B12 Depletion:
A final word of caution, though. There are some nutritional consequences of metformin therapy. The primary concern is vitamin B12 deficiency, especially at doses of 1500 mg or higher (Medicine, Nov. 2019).
Abigail inquired:
Q. I have read that metformin can cause a deficiency of Vitamin B12. I have not been able to find again the source of this information and would like your input.
A. This is from the prescribing information at DailyMed, identical to what is published in the PDR:
“Vitamin B12 Levels: In controlled clinical trials of metformin of 29 weeks duration, a decrease to subnormal levels of previously normal serum Vitamin B12 levels, without clinical manifestations, was observed in approximately 7% of patients. Such decrease, possibly due to interference with B12 absorption from the B12-intrinsic factor complex, is, however, very rarely associated with anemia and appears to be rapidly reversible with discontinuation of metformin or Vitamin B12 supplementation. Measurement of hematologic parameters on an annual basis is advised in patients on metformin and any apparent abnormalities should be appropriately investigated and managed (see PRECAUTIONS: Laboratory Tests). Certain individuals (those with inadequate Vitamin B12 or calcium intake or absorption) appear to be predisposed to developing subnormal Vitamin B12 levels. In these patients, routine serum Vitamin B12 measurements at two- to three-year intervals may be useful.”
Vitamin B12 deficiency can contribute to numbness, tingling or pain of the toes, feet or fingers, trouble walking, memory problems, depression, confusion and burning tongue. Anyone experiencing such symptoms while on metformin should ask the prescriber to check on vitamin B12 status.
Another reader wrote about her husband’s trouble with metformin and poor kidney function:
Q. My husband took metformin for years with no known side effects. Then his kidney function started to deteriorate, so he was seen by a specialist who immediately took him off metformin. He said that this drug was very hard on the kidneys and anyone who had any variations in kidney functions should not be taking it.
A. As mentioned above, kidney function must be monitored regularly to prevent just such a complication.
Digestive distress associated with metformin (Glucophage) usually eases with time, but sometimes it persists:
Q. I am suffering from such severe diarrhea I am sometimes afraid to leave the house. I also have bad gas and bouts of abdominal pain. I suspect the metformin I take for diabetes, but my doctor says my symptoms are not from my medicine.
The Prevacid I take for my heartburn isn’t helping enough to justify the expense. I am also experiencing pain and tingling in my toes.
A. Metformin (Glucophage) can cause diarrhea, nausea, heartburn, flatulence and stomachache. Acid-suppressing drugs like lansoprazole (Prevacid), omeprazole (Prilosec) or esomeprazole (Nexium) won’t solve the problem completely and may interfere with absorption of vitamin B12.
The Miracle of Metformin Against Cancer:
Before you give up on metformin because of side effects and scary stories, we want to tell you about some surprising benefits of this drug. There is growing evidence that it may have impressive anti-cancer activity. In particular, there are data suggesting that metformin may lower the risk of developing breast cancer, liver cancer, pancreatic cancer and colorectal cancer in people with diabetes and that the overall risk of developing cancer in such patients is substantially lower. Not only does the drug seem to reduce the risk of developing a number of common cancers but it might reduce the spread of cancer once it is diagnosed.
Researchers are beginning to tease out one of the proposed mechanisms for the anti-tumor action of metformin, especially in prostate cancer. One study involving “388,760 men who participated in national health screening program in Korea during 2002-2003 were observed from 2004 to 2013 (Scientific Reports, Aug. 9, 2021). They looked at “aspirin, statins, and metformin use on prostate cancer incidence and mortality.”
Statins had no noticeable impact on prostate cancer.
The authors offered this result:
“In conclusion, metformin use was associated with lower PC [prostate cancer] incidence. Use of aspirin and that of metformin among diabetic patients were associated with lower PC mortality.”
A study in the journal Prostate Cancer and Prostatic Diseases (Jul. 28, 2015) reported that effective treatment for aggressive or advanced disease is challenging.
The researchers note:
One potential target is the cancer stem cell (CSC). CSCs have been described in several solid tumors, including prostate cancer, and contribute to therapeutic resistance and tumor recurrence. Metformin, a common oral biguanide used to treat type 2 diabetes, has been demonstrated to have anti-neoplastic effects. Specifically, metformin targets CSCs in breast cancer, pancreatic cancer, glioblastoma and colon cancer.”
By exploiting a metabolic weakness in cancer stem cells, metformin theoretically makes these problem cells more vulnerable to conventional cancer therapies and could reduce the likelihood of cancer resistance and recurrence. One study found that women with endometrial cancer were less likely to have a recurrence if they were taking metformin (International Journal of Gynecological Cancer, Feb. 2016).
The latest research with metformin against prostate cancer is very encouraging. Men receiving radiation (external beam or brachytherapy) fared far better than the men not taking metformin (Canadian Journal of Urology, Oct. 2018).
The Latest Chapter Is Anti-Aging Activity:
It almost sounds too good to be true. Could this old diabetes drug actually slow down biological aging?
In a review article in the journal Postepy Higieny i Medycyny Doswiadczainej (online, March 3, 2017) the authors note:
“Interestingly, there is a quickly growing body of literature demonstrating its potential in the therapy of multiple disorders other than diabetes. Many epidemiologic analyses have reported that metformin may improve prognosis of cancer patients and also may prevent tumor initiation. Moreover, there is evidence suggesting that metformin acts as an anti-aging factor and modulates the microbiota, promoting health. Thus, metformin is currently being investigated for new applications.”
The authors describe potential mechanisms for an anti-aging action of this medication along with ways the drug could combat cancer. They characterize metformin’s potential on both fronts as “promising.”
More recently, Canadian scientists studied the effects of metformin on ovarian fibrosis (Clinical Cancer Research, Oct. 9, 2019). The research was conducted in mice, not women.
However, the researchers concluded, it
“suggests a potential use for metformin in ovarian cancer prophylaxis.”
The Bottom Line on Metformin (Glucophage):
Metformin is an old diabetes drug that is being rediscovered for its potential role against cancer. Only time will tell whether it will live up to expectations. Will it turn out to be a fountain of youth? Doubtful, but if it can improve longevity, that would be an added bonus.
In the meantime, metformin remains one of the least expensive prescription drugs in the pharmacy. As long as people are vigilant about side effects and complications, it could become one of the most intriguing drugs on pharmacy shelves. Here is a link to our article “Is Metformin a Modern Miracle Medicine?”
To learn more about metformin and many other ways to keep blood sugar under control, you may wish to read our eGuide to Preventing and Treating Diabetes. This online resource is available under the Health eGuides tab at this website.
Lisa H
I took Metformin Extended Release 500 mgm for 10 short months. Ended it mainly because of the nutritional side effects…B12, Coq10, and Folate..which I had previously discussed with my doctor prior to taking this medicine. While on it, I did supplement with all three supplements. I went on a keto diet, lost 33 pounds over the course of five months. It came off slowly but my doctor was very pleased and told me to keep doing what I had been doing diet lifestyle wise.
I manage my food intake very seriously, having had to come off all wheat and grain foods. On occasion, should my fasting number be a bit high (due to the Dawn Effect), I supplement with Berberine. It works very similar to Metformin with no side effects.
Elizabeth
My Mom had her kidneys and health destroyed by Metformin. She used Motrin 800 due to side effects of this horrible drug! Then she was put on Avandia and began having strokes! Sadly her “diabetes specialist” cared more about his fees for speaking on behalf of the drug companies than he did for his patents!
My Mom died during a test to locate the cause of an infection she got when she had to be put on dialysis due to her failed kidneys! Her multiple strokes after being on Avandia were never caught by her specialist either!
I blame the drug companies and a bad Dr for my Mom’s early demise due to kidney failure and heart issues! These are not acceptable side effects of drugs. tThey are deadly to many people like my poor Mom! When I briefly got type 2 due to a health issue I refused to take the drug that killed my Mom!
My Dr agreed it was a dangerous med for me, and after my health issue was rectified my type 2 went away!
M
Does anyone notice a fishy odor with their Metformin?
I take the extended release and have noticed a strange odor when I open the bottle. This has happened on monthly renewals as well. Any thoughts?
CAROL
I lost 40 pounds when on Metformin, and it caused such severe diarrhea that I couldn’t leave the house. Ultimately, a substitute doctor happened to see my records and called to tell me to stop taking Metformin immediately and see a kidney specialist as soon as possible. Too late. My kidneys had already been damaged! I now have Stage 4 kidney disease. It’s too bad that my regular Primary Care physician didn’t catch this soon enough.
Janine
I have taken metformin for most of the past 20 years for my Type 2 diabetes. I have two observations that may be helpful.
First, several years ago a new provider switched my ER (extended release) version of the medication to the regular without my notice initially. Suddenly I was experiencing gastrointestinal issues daily that I had never had before, so much so that I would review my day before deciding whether to take it or not. When I realized the change in formulation and went back to the extended release, these problems immediately disappeared. My PCP decried that the extended release was less effective, but everything I read showed a negligible difference in these numbers and when compliance in taking the medication is factored in, the difference is even less important. She then agreed to switch me back to the ER formula.
Second, eighteen months ago, I questioned my endocrinologist about the need for metformin since I now take insulin as well and stopped taking it with her blessing. My cholesterol numbers shot up. This was the only change in medication or lifestyle made at that time and I found research indicating that metformin can reduce cholesterol levels. Since I cannot take statins due to adverse side effects and had maintained my cholesterol numbers, unknowingly with metformin’s help, I went back on the metformin for this benefit.
Dennis
A year and a half ago, I was told I had 2 years to live due to Stage IV prostate cancer. The day I was diagnosed, I asked the Urologist if I could go on Metformin. He said, “Great idea.” 5 months after the initial diagnosis my PSA’s were down to an undetectable level where they have since remained. The cancer in my 2 infected lymph nodes have continued to subside and I’m living a normal life. I’ve also adjusted to a plant-based diet (in order to change my body chemistry) and have, thru meditation, affected my internal mental dialogue which I know has also had a positive effect on my health.
My negative med-induced symptoms seem to be related to Lupron, a hormone injection which kills testosterone: Hot Flashes and occasional fatigue.
Occasionally I’ll have abdominal stomach cramps that I attribute to Metformin but that’s about it. I’m one of the lucky ones — and given the trade-off, it’s well-worth it for the results.
Ray
Gee, didn’t I hear STATINS were an anti-cancer panacea just a decade or two ago?
Jackie
I was prescribed Metformin when I developed type 2 diabetes (after being put on statins due to family history of heart dusease). I experienced severe diarrhea as well as swelling of feet and ankles and a severe itchy rash. Reported all side effects to doctor. Was told they would subside once my body got used to the medication. It never did. Doctor prescribed 800 mg Ibuprofen 4 x day for swelling, sent me to dermatologist for rash, and told me to use OTC meds and learn to live with diarrhea.
I was on Metformin for about 3 years, until my kidneys began failing. Doctor sent me to kidney specialist who took me off Metformin and all NSAIDS. My kidney funtion improved immediately, but I had to go on insulin. My question is: Why do doctors ignore warning signals clearly printed on prescribing literature and simply prescribe another risky medication to mask troubling (even dangerous) side effects?
I took myself off of statins due to debilitating joint pain and muscle weakness which put me in a wheelchair. Recently statins have been implicated in development of diabetes. I am tired of doctors saying “the benefits outweigh the risks.” Not when the risks are life-threatening, or cause other conditions to impact a patient’s ability to function normally! As patients, we must take an active role in our healthcare, read the literature, speak up and ask questions, and resist 1 size fits all, cookie cutter solutions. If your doctor is not confortable answering your questions, or refuses to listen to your concerns, find another doctor who will!
Iris
I am taking Metformin 500 mg a.m. and p.m. After taking the a.m. dose I develop diarrhea. A couple of hours later I go for a bowel movement 3 times before noon and then none rest of the day. I do not take the p.m. dose.
HELP! I have taken Imodium the night before and have not had diarrhea the next morning. How often cam I take Imodium???
Joseph Koran
TN
Has anyone who has gout experienced flare-ups with Metformin?
Kay
Minnesota
I started taking metformin to keep my blood sugar in the normal range because another med I was taking put my blood sugar thru the roof.
I too suffered with continuous stomach upset and violent diarrhea.
I could no longer leave the house safely without taking meds for the diarrhea. There were accidents. I tried it with food. I tried the slow release…..no help. Then my potassium started dropping .
My doc prescribed another drug. It is low-priced and effective.
After 6 weeks the diarrhea has stopped.
There is no reason to take a drug that causes this many problems and chains you to your home. No responsible doctor should make you suffer. Change meds or change doctors.
Betty
Illinois
My husband is also dealing with extreme diarrhea, weakness, aching, chills, nausea–it goes on and on. He’s tried many different ways of using Metformin- ER and different doses . What med did your doc put you on?, we need some help.
Debbie
New Mexico
I took Metformin for years, but then I started to have severe diarrhea. I did not know what was causing it but I was having a lot of accidents and got to where I could not leave the house. Had a colonoscopy, and all was fine but still had severe diarrhea. My doctor felt it was the Metformin and took me off of it and prescribed something else. He told me it would take a while to get it out of my system, and if it was the Metformin then the diarrhea would eventually go away. He was absolutely correct. I after 3 months I no longer am having an issue. So nice to get my life back.
Someone
Ia
Berberine is just as effective and has other benefits.
REAL
DULUTH MN
I have taken Metformin for about five years, usually 2 grams a day. But sometimes less because my blood sugars were getting too low, for unknown reasons. Meanwhile, my health has continued to improve in many areas. I attribute that to improved diet, supplements, meditation and thinking.
carole K.
Sydney, Australia
Don’t forget it can be useful for women who want to get pregnant.
SHARON
janesville, wisconsin
I have been taking metformin for about 6 years. I do have the side effect of diarrhea and low B12. I take B12 supplements and that solved the low B12. The diarrhea is another story. Time release has helped. Also taking a lower dose more offen seems to solve the problem most of the time. Foods that can cause loose bowels can cause a problem combined with the metformin. Using time release and taking a 500mg pill with meals is better than taking 2 pills in morning and 2 in evening. You need to be dedicated to remember to take more offen but that is better than taking pills for side effects or another diabetic drug.
Mary
Greensboro NC
My husband has not had symptoms associated with metformin, but he has plenty. He just trusts his doctor. Has anyone heard of or tried Vedda blood sugar remedy?
Harvey
North Ridgeville Ohio
Functional physicians all over the country are curing Type 2 diabetes with a Ketonic diet and some are adding intermittent fasting as an adjunct. The Cleveland Clinic offers a 12 week program for outpatients to learn how to do it. It is interesting that all of the benefits ascribed to Metformin are attained by a ketonic diet- weight loss, longer life, some cancer control, total reversal of Type 2, better lipid numbers, anti-seisure, mental clarity, autism, etc.
It sounds like science fiction but it is all covered in a documentary on Netflix entitled A Magic Pill. This is how we were meant to eat.
Reagan
Hendersonville, N. Carolina
Instead of metformin which has too many side effects, consider vitamin B1 also called thiamine. at
http://orthomolecular.org/resources/omns/index.shtml for noncommercial information by Stuart Lindsey, Pharma
R. Houston
Anita
WI
I was diagnosed with Diabetes, Type II, twelve years ago. I could not tolerate regular Metformin so switches to 500ER, twice daily, WITH MEALS. The diarrhea stopped. The clue is: WITH MEALS. I usually take mine about five minutes after I start eating. My A1C has remained between 5.3 and 5.7 ever since. I am excited about new research that show its anti-cancer, anti-aging, and anti-Alzehimers as my mother has Alzheimers, as did her mother, and my father died of cancer.
Julie
ny
I never had any blood sugar issues. Then a psychiatrist put me on metformin to prevent weight gain on the psychiatric drugs he gave me, but I gained a ton of weight anyway, the Dr. said that without the metformin I would have gained even more but I very much doubt that would even be possible. Since then my blood sugar gets in the high range of 100-104. I still have a lot of metformin and hear so many reasons to take it and that it improves the gut microbiome. My health is so poor and I want to do whatever I can to improve it, so not sure if I should take the metformin.
helen
USA
Both my husband and I were taking 250 mgs, a.m. and p.m.of Metformin for five years. We took it for the reported anti-aging benefits and also to way-lay metabolic syndrome, an issue we did not have, but others in our families did.
After about three years we both started to experience leg weakness, and we would get fatigued more easily in general, even though we work out with heavy weights four times per week and use an elliptical trainer five to 7 days per week. We also noticed tingling in our hands and feet, as well as joint pain.
We did not at first make the connection to Metfomin. We are both in our 60s and assumed it was all part of normal aging.
Finally, I did some additional research about Metformin and found many similar complaints online. We stopped taking the Metformin, and within a month our legs felt strong again and the numbness, tingling and joint pain resolved.
Has anyone else experienced this? Much of the research seems to show Metformin as a miracle drug with anti-cancer and anti-aging benefit.
S
Utah
I had gestational diabetes whIle pregnant 3 years ago. I was told my blood sugar has been high since and prescribed metformin. I’ve only been taking it for a few days and already have diarrhea. I have had acid reflux my whole adult life (I’m 38 yeas old) so I’m hoping and praying I the diarrhea will subside after the first month and I’ll be able to keep taking it. I’m so happy to learn of these amazing benefits of this drug. My doctor told me I can reverse the diabetes with diet and excersize so I’m trying hard to get my weight down. (Need to loose 60+lbs) I also have high blood pressure and a fast heart rate that I’ve recently started medication for. I’m too young to have these problems. My weight spiraled when I went through severe hormonal imbalance just after I’d given birth. It was like I gained 40 lbs overnight.
Mary
South Carolina
S from Utah,
I also had gestational diabetes but refused to take insulin (which doctor advised) or metformin. I, like you, ballooned up in weight after giving birth. Went from 220 to 275 in a matter of 2 months. I ended up trying low carb and was able to get back down to 215 in about 6 months. I was able to keep it off but now my doc has put me on a statin which is raising my glucose again. I am going to go back to low carb and see if I can get my glucose back in line. Have you tried low carb? It’s tough when you first start but gets easier. Don’t give up! Best of luck to you.
Mosibudi M
South Africa
I have just started taking metformin on Saturday and have had severe headache and bloatedness. Can it be the side effects of metformin?
Pat
New York
Second day here and terrible bloating tonight.
Michael C.
Brooklyn, NY
Glucophage is made in the USA and a better drug than metformin. Where is metformin made?
KARL
SYRACUSE,NY
India and China, they have additives that can make you sick. I switched to Glucophage because generic metformin gave me severe diarrhea.
Liz
Fort St. John, BC
I have been taking metform for approximately 6 months now and have found that my teeth are becoming increasingly sensitive, the pain is at time unbearable a it can vary as to where the pain actually is. They appear to be effected by both cold and hot but the cold is worse.
Virginia
Texas
I took metformin for about 2 and one half years. Started in 2009 and at the end of April 2012 it shut my kidneys down and my blood pressure was bottoming out and I went into a coma!! My kidneys were full of metformin that didn’t flush out! The only thing they could do was one treatment of dialysis to see if that would flush it out of my kidneys. Thank the good Lord it worked or I would have died. I was taken off of it and have tried other kinds of diabetes meds since!! It needs to be taken off the market! I was in the hospital for 8 or 10 days!!
Vicki
Leeds,England
I was prescribed metformin in June 2017. I took 1-1000mg tab in the morning for 1st wk,2nd wk,1-1000mg tab in the a.m.&another tab before bed.3rd wk,1 tab a.m,1 tab afternoon&1 tab before bed. O.M.G.!!! I had a terrible reaction immediately. nausea,chronic cramps&chronic diarrhoea!! couldn’t work,couldn’t sleep,didn’t DARE leave the house!! told doctor who seemed disappointed rather than concerned,then prescribed only 2×1000mg slow-release metforin. still not much better. having to “run” to toilet upto 9 times a day caused by chronic diarrhoea!! metformin has to date surpressed my appitite to the extent that since June 2017-present I have lost 3 stone,& I was sent to hospital for kidney disfunction&de-hydration. medical action still on-going. NOT A FAN of Metformin!!!
Edward
Should a Drink a Beer To Keep Kidneys Flushed .water won’t work.
lorraine
cm202lb
My mother was recently prescribed metformin being told that she has diabetes type 2, but since being on them for at least three weeks she has been suffering panic attacks cant sleep scared to go out breaking down all the time she is an eighty two old who went swimming every other day first thing in the morning and now this week she went to see the dietitian at the doctors and has now been told she dose not have diabetes at all and she shouldn’t have been prescribed them at all she is so scared being on her own now she is falling to pieces.
Edward
Arkansas
10 To 12 Non alcoholic Beers a day .
Dee
canada
Isn’t that full of carbs and sugar?
Maria M
NY
I had been using metfformin For 8y but sometimes I have, gas, pain, nausea, and very small stomack dropping. Yes and always sick and sleepy but metfformin is good when my sugar is high?????
Carol
NC
I am trying very hard to take as few prescriptions meds as possible … i was put on 500mg Metformin about 2-1/2 years ago after reaching Type II range (6.7). i began a low carb/high fat diet and took the Metformin and within 3 months, A1C down to 6.2. it has remained stable for over 1-1/2 years but i just had diagnosis and removal of pretty large kidney stone.
I’ve never had any issues with my urinary tract so have now taken myself off the Metformin and will see how my A1C is next time, if it is stable or lower, i will keep myself off Metformin and go more strictly with lifestyle changes. I do not want another kidney stone if I can ward it off.
Vivian
California
I have been on Metformin for 12 years. I was on 1000 mgs twice a day but realized it was causing me so much bloating and burping. Now i take only 1000 mgs with evening my meal. My bloating and burping are almost non existent.
Also, i was taking a prilosec type antacid and the pain in my body and bones was intense due to the calcium and b12 absortion being blocked. I now use Ranitidine 150 mgs twice a day and their is no more pain in my bones. My daily vitamins are a multi vitamin, b-complex, b12 sublingual 5000 mgs and d3… I have been a type 2 diabetic for 12 years and the circulation in my lower extremities is pretty good.
I have been insulin dependant for approx 3 years. My a1c’s range from 6.8 to 7.2. I don’t try to be perfect with my diabetes because i dont like the feeling of having to be so rigid… ☺
Kidane G
Grayson, GA
I have night-time dry mouth, and I pee like 0 – 3 times a night. One time I went to visit a doctor to do a regular check up. I gave blood, and I did not even tell the doctor about the dry mouth and increasing pee I have, because I was not suffering that much. Anyway, after around 2 – 3 days the doctor called me and told me I am prediabetic. So prescribed me Metformin. I told him that I can exercise but he said that Metformin can help me to lower the sugar in addition to exercising.
As soon as I started to take this medicine I felt a lot of depression, had nightmares, and I am going to restroom to pee all night. Remember, I never had that much problem before this medicine. I was sleeping much better. I immediately stopped this medicine. Right now I am thinking how would I get this medicine out of my system . Because I don’t see it helping me, instead it dropped me to the complete disease of nightmares, depression,peeing the whole night, I am not sleeping because of pee. I have to visit this doctor again . Guys if they told you that you are pre diabetic, and they told they are going to prescribe you Metformin, think about my honest experience. It may happen to you too.
Lynette
Brisbane, Qld
I first became a diabetic type 2 when I was in early 40s. I was taking metformin 3 times a day then. I started getting chronic diarrea and put up with it for 12months. Went to doctor and had to have a colonoscopy and that came back normal. I was referred to a specialist and he put me on a new medication at that time and BINGO never got diarrea again.
Over the years, tried a few different medications and they made me hyper so 2 years ago I tried metformin again but did the same thing. But then I tried the slow release metformin and it is excellent. I only take 1x 500mg in evening.
Ed
Panama city fl
I have been on metformin for 1 month. I am bloating lots of trapped gas. My A1c is 6.5 and I am needing to lose 30lbs to help my fatty liver. I take Nexium and hope the metformin will work together as I have been taking Nexium for about 10 years.
Sharon
Missouri
I was diagnosed with Type II Diabetes in 2015. I take 500mg metformin at dinner (larger doses make me sick). It’s been almost 2 years and I have gained weight and have several other side effects from this drug. I count my carbs, try to walk approx 3 miles 2x a week. I live in a remote area where you can’t just go out and walk. I’m on a fixed income so I can’t always buy the foods that I need to be eating, but I try. I can’t work out due to a broken wrist that did not heal due to a Doctors incompetency. My blood sugar just won’t go down. My dad passed away due to complications of the diabetic drugs given to him, so I’m very cautious about taking prescription drugs for this condition. I know that there has to be a herbal supplement that can do the same thing, as I have found other herbal supplements that have done wonders for other issues. Just wondering if anyone has tried a herbal supplement for their type II diabetes. I know if I could lose the weight that would help significantly, but I can’t lose the weight and as I said have increased my weight since taking the metformin
Joyce
Myrtle Beach, SC
I’m a plant-based nutritionist, who became vegan nearly 7 years ago. My cholesterol at that time was 252. After eliminating meat, fish, and dairy (occasionally I will have crab meat or shrimp), I lost 10 lbs. A year later, my cholesterol lowered to 162, and has remained there ever since. I recommend to the lady who walks 3 miles 2X per week, to walk 2 miles, 3x per week. Diabetes II is a disease caused by consumption of too much fat and sugar. Once you stop eating animal fat and animal byproducts, such as eggs (egg whites are fine), and begin a regular exercise routine, your diabetes will go away. No more insulin, no more drugs. Eat vegetables, fruits, whole grain pasta and pizza (with no artery clogging cheeses). Top the pizza with as many vegetables as possible. Eat whole grains, such as quinoa, oatmeal, whole grain breads (no butter), avocados, olives, and very little oil. You will be thin, feel marvelous, can eat as much as you want, and be diabetes free.
Dave
Florida
Sharon, I share your thoughts about prescription drugs also. I’ve heard from reputable sources that non-prescription Berberine with cinnamon will lower your blood sugar. I have not stopped taking Metformin yet until I talk to my doctor about switching to Berberine. Hope this helps.
Heather Lyn M.
Michigan
Sharon, I take 1000mcg of chromium picolinate at night with my pm meds. It has dropped my glucose readings by 15-20 units BID.
Edward
GYMNEMA, CEYLON CINNAMON, VANADIUM,CHROMIUM,BERBERINE,BITTER MELON
AVAILABLE ON AMAZON. THEY ALL WORK .
Orlean
GA
I went on Metformin when my A1C went up to 6.2. There were no sign of me being a diabetic, no symptoms that there was anything going on. After 3 months on 500 MG 3 times per day, my A1C dropped to 5.9. She checked my kidneys, then started me on 500 MG twice per day.
At first I was nauseated and had stomach cramps, then that subsided. then a few days later I started having diarrhea really bad. After the diarrhea came the heart burn which I think is the worst so far, even without eating I get the heart burn. The latest one is feeling like my bladder is full, and when I go to empty it there is only a drop of urine and I still feel like there is pressure. I go back in July to have my kidneys and my A1C checked, and I am hoping that my A1C is lower than 5.9. I need to get off this medication to start feeling like myself again. I like the fact that it seems to help with all the different cancers, because that runs rampant in my family.
I wish everyone good luck with or without this medication, I only wish that I could find something that would help my heart burn, nothing seems to help.
linda
herne bay
Hello. Me here, Linda,
I have been a diabetic about 5 years now. Is anybody out there could answer my question? I have been on 4 metformin med plus two other diabetic tablets, and in all that time the sugar levels have never gone down. I just wondered if anybody else has suffered this problem. My GP is now looking at insulin. After all this time, my first HBAC1 was 60, then 70,80, now 97. It does not seem right.
Mark Law
marklaw@hotmail.com
Try omeprazole for heartburn I guarantee goes away. Mark from Missouri
Dianne
Ontario
I have been on Metformin for 3 years. Had cramps and headaches first few mths then no issues until about a year ago. Very bad pains near my belly button. Had colonoscopy, and they said all was clear. I have had the issue with peeing every 10 min. It drives me crazy. When I walk I feel like there is pressure to pee. I went off it on my own 4 days ago, and now I feel light headed, fatigue and have rapid heart beat. I went from 165 to 147 lbs and adopted a plant based diet.
Tested blood a few months ago, and my doctor said it was great. Wondering if I should have stopped cold turkey.
Jean
Florida
I have been taking Metformin for approximately 2 years. My biggest problem is GI related. I was tested with the ECG and it was found that I have 4 healing gastric ulcers and 1 active following the use of Omeprazole. Recently I have been having severe leg cramping at night while asleep. I have regular lab work and am scheduled for labs and Doctor visit in July. I dread what will show up.
Connie
Ontario
I drink apple cider vinegar and it gets rid of my heartburn.
Francesco
ny
Hi,
I need some advice on the Metformin. I’m 70 years-old and diabetic since 2004 and have been taking Metformin hydrochloride extended release from the start. But just recently my mail order pharmacy has refilled my order with metformin hclor metformin hydrocloride hcl er all a 500 mg. Who can tell me what is the difference, and if they are the same? Thank you very much.
P.S. I’m assuming that what I have been taking for 18 years is the equivalent of glucopage?
Anne
Denver, PA
I’m 66, have multiple autoimmune and other chronic diseases (hypothyroid, hypertension, vitaligo, history of alopecia areata, osteoarthritis, ulcerative colitis, stage 1 primary biliary cirrhosis, stage 3 kidney disease, elevated cholesterol and triglycerides, and associated heartburn, fatigue, anxiety). I’ve also had long-term insomnia. Now I also have diabetes type 2. Was started on Tradjenta last year and my blood sugar was better. But after some steroid injections for the OA, and antibiotics for URI, and narcotic pain meds for severe dental pain (failed/extracted implant and bone graft), my sugar rose significantly and had still not come back to my new “normal” after several weeks. My Endocrinologist added Metformin to my already long list of meds. After 4 days it seems to be lowering my blood sugar but I am having terrible GI results (worsening heartburn, nausea, diarrhea – was in ulcerative colitis remission for 3 years till now, and nearly vomitted today). I won’t be able to reach my doctor till next week but I’m not planning to take any more metformin until I do reach him. I’m also concerned because my kidney doctor told me I should not ever take the usual diabetes drugs because of my kidney disease. I do exercise and try to eat well, trying to lose my extra 25 pounds. I was grateful to be in relatively good health despite all my diseases but I fear the results of uncontrolled diabetes if I can’t tolerate effective meds for that problem.
Ed
Florida
Yes I was having bad leg cramps but I started taking 2 tablets of magnesium and potassium morning and night, and they have gone away. I still have one occasionally but usually when I miss my dose, good luck.
Dianne
Ontario Canada
This does work. The magnesium also works to aids in constipation, insomnia and helps calm you. Doctor recommended this, and it works for me.
Mary
I also need to take magnesium regularly or I will get leg cramps. In my case, I also need to keep my salt intake a bit on the high side by lightly salting my drinking water. Just salted foods is not enough.
Have since added 500 mg potassium in the mornings. So far, mostly good.
Peter
Australia
I have been on metformin for a month and my bsl went from 24 to 12. My doc put me on the extended release plus nesina in the hope of getting bsl lower. I take effexor for depression, somac for heartburn to control barrett’s esophagus, exforge and perindorial for systolic hypertension and arthritis upper, lower back with a degenerative facet joint C2. I plan on taking the fist script of extended release and nesina the doc gave me and see if the side effects settle, if not look at alternative and if no alternative
Jackie
Texas
I have been taking Metformin ER 500 mg- 2 tablets at dinner. My knee and finger joints are sore. I have Osteoarthritis but the pain has never been this intense. I read that Metforman can cause joint pain. Will this go away after I have taken the meds for awhile? Has anyone else had this problem?
cindi
VA
I was on Metformin for a number of years, 1000mg twice a day. I had frequent diarhea but I also don not have a gall bladder. I began using a fat enzyme to correct believed effect of no gall bladder and was better. Then my new doctor put me on Metformin ER 500 mg 4 a day. I began to vomit about every 5-6 days. I went off the Metformin ER for 2 days and the vomiting seems to have stopped. I am getting a replacement for Metformin.
Karen
Beggs, Ok
I too had some finger and knuckle pain like arthritis soreness and inflamation. Hard to pick up a cup of coffee with the sharp pain hitting. Then I started taking Tumeric,black pepper, coconut oil which I followed recipe on the internet and filled my own blank capsules. After just two weeks the joint pain went away and only comes back if I fail to take the capsules for 3 or more days. I take one in the am and 1 in the pm. Amazing…never have taken meds before Metformin and never try supplements for pain but it really works for me. I am 65 and relatively healthy except this prediabetic concern which I hope the Metformin helps. The diarreha stopped after the 5th week.
Rich
Omaha
Stopped metformin due to intestinal issues. Also nerve pain in feet went away.
Brenda A
NJ
Stopped taking metformin 4 months ago. Started taking glucocil. After 4mos had my A1c checked. Went up .7. Dr encouraged me to start metformin again. A1c recheck in 2mos. Hoping for an improvement.
Stephanie Grey
USA
I started in November 2016 and have lost five pounds so far. I hope it will prevent fatty liver and help me lose more weight. My AIC reduced from 6.3 to 5.9 but I take it for other reasons and to help reverse diabetes and complications. its been around a very long time, it must be all they said it does.
adele
Michigan
I have been on Metformin for about 6 months and I take no other medications (other than a daily aspirin); my A1C was 6.7, but was down from three years prior (8.3) due to major diet changes (Dr. Fuhrman eating plan and losing 20 pounds). I am anxious to see my A1C in the end of this summer, as I’ve been off the good eating plan, but avoiding sugar and white flour most of the time, and have had a rather sedentary winter.
This morning, I woke up with puffy hands and face and became concerned . . . thus the search for Metformin side effects, which lead me here. I hope the side-benefits of Metformin are true; what a plus!
Eric Hooper
California
I was on met Forman it made my hair start falling out also started getting sores on my head .how long do the is side effects last ?I have whet on a diet and lost over 120lbs and I am no longer diabetic I have been off met Forman for three months and my md.says I am borderline to being diabetic but I am still having the side effects no one in my family has ever been bald and I honestly hope that I won’t be the first has anyone else had the same side affects ?my md.said that the sores on my scalp could be toxic discharge from losing weight and my body is getting rid of toxins but I don’t believe that. ..
Paul C
Garland,TX
I’ve been taking Metformin for more than 5 yrs, and haven’t noticed any particular
side effects. It has been part of controlling my blood sugar. I hope it does have
some of the side benefits that have been discussed here. I’m looking to live taking
Metformin for 40+ years,if Drumph gives me the chance!
Carol
NC
Try low carb, high fat lifestyle diet to lower A1C … See dietdoctor.com for loads of information.
Jan
27215
I don’t have anything good to say about Metformin. It was given to me because supposedly I was borderline diabetic. It made me very sick. I also slept all the time and my stomach stayed upset. One doctor tried to give it back to me and got angry when I said no. I am beginning to think that it is more important to make diabetics than it is to make people better. I was told by several doctors that I was diabetic. Once you are tagged as diabetic, they don’t want you to be undiabetic. I finally found a doctor that thinks my numbers are fine. All I am saying is that doctors don’t care how you feel and they don’t care if the side affects are bad. They just want you to take the medicine.
Mary
NC
A close friend was having a rough time with newly diagnosed diabetes, and she was having awful side effects from metformin. While still pre-diabetic, she’d been trying a paleo diet, but her blood sugar just kept on climbing. She found Dr. Greger’s book, How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease and his educational videos such as http://nutritionfacts.org/video/reversing-diabetes-with-food/
After just a week trying Greger’s recommendations, her blood sugar levels were stabilizing, and her A1C levels are completely normal after a couple of months, no medications needed now. Food for thought.
Susan S
VA
My husband used metformin successfully for years, his A1C just below the pre- diabetes range. When he read about its anticancer activity, he doubled his dose with his doctor’s blessing. At first there were no problems, but it took a eight-month bout of diarrhea and a visit to a digestive health clinic before the cause was identified as metformin and he was told to return to his original dosage. Meanwhile he had serious complications: six weeks of C. diff., nearly undiagnosed because of diarrhea. Low blood pressure from lost electrolytes landed him in the ER. He was deconditioned due to low blood pressure. Probiotics didn’t help. The diarrhea continued until he also stopped eating yogurt.
Mary
Dr Richard Bernstein, an 80+ year old Type I Diabetic, says to take the brand name drug and not the generics for diabetes management.
Remember how many complaints about generics in general have appeared here?
Larry
central New York
I’m 69 years old, and I too have GI problems with Metformin. I’ve been using it for about 4 years and initially was taking 500mg 2x a day and tolerated it quite well. The doc raised the script to 1000 mg 2x per day, and the diarrhea and gas began. My doc told me to take Metamucil fiber wafers to boost fiber intake which supposedly absorbs excess water in the intestines. Works somewhat but not 100%. On my own I began taking probiotics, the ones for adults over 50. This seems to mitigate the symtoms somewhat too but not 100%. Sometimes taking 1 pill 4x daily seems to alleviate the GI problems but, once again, not fool proof. Good to hear about the anti-cancer properties because I have a family history of kidney & colo-rectal cancers.
Sabrina
San Diego
I was diagnosed with prediabetes Type 2 and prescribed 500 mg Metformin a day. My Ac1 was 7. Also prescribed Simvastatin and hydrochlorothiazide and told I had Metabolic Syndrome. I watched my diet but next Ac1 was even higher.
Side effects of Metformin were constant dairrhea to the point that I couldn’t leave the house, hair loss, belly ache. I did some research and found that the statin and water pill raised blood sugar. A year into this my primary care provider moved away, and I quit all drugs and went with Nopal Cactus, apple cider vinegar, cut out dairy and feel great. I did this for 2 years before finding a new Doc.
I now have a new primary care and a diabetic nutritionist I see. Both amazed that my A1C is a 7, I’m on Losartin for blood pressure and working on the cholesterol (270). They don’t insist on Metformin or anything else for diabetes.
So many people have written about their doctors ignoring them. When I first met my new primary care provider we talked for about 30 minutes. She listened as I explained how I felt about Doctors and big pharma and taking meds. Told her my medical history (cancer survivor) and then she said “I think we are going to be a good match”. I was floored. The moral to this story is if your provider doesn’t listen to you, get a new doctor until you find one that does. Thank you, Terry and Joe, and everyone who contributes
David
Richardson
I also had gastrointestinal problems with Metformin until I switched to the extended release formula. Now I have no symptoms at all. With Metformin, diet, and exercise, my A1C numbers have been kept in the normal range (4.4 – 6.4%) for several years. I would recommend asking your doctor about the extended release formula before giving up on metformin. It is available as a generic.
Emory T.
Metformin caused extreme indigestion, I was still burping up the taste of breakfast when my stomach was growling for lunch.
Greg
Wisconsin
Metformin worked well for me, for about 10 years. It always caused me some stomach discomfort and flatulence. Then in November, 2016 I ended up in the hospital with severe vertigo and test results showing high levels of lactic acid. My doctor suspected lactic acidosis and took me off the drug. I’ve now found that none of the newer drugs work as well, and I’ve been started on insulin to get control of my blood sugar levels.
Steve
Chicago
Was diagnosed with Type 2 diabetes about 4 years ago (at age 65, blood sugar was 320 on blood panel). Naturally, my doctor put me on Metformin (low dose, 500mg). After a few days I was having terrible stomach problems, mainly nausea and bad diarrhea, feeling deathly ill. Worst side effects I have ever had from a medicine, and I have been on many (blood pressure, depression, anxiety). I went off it after a week, problems disappeared after 3 or 4 days, and have since controlled my diabetes with diet (low carb) and exercise. Last A1C was 5.6. More power to you if you can take this stuff.
Richard
Dallas, TX
Metformin can also cause kidney failure. My late wife was taking Metformin for several years when her doctor upped her dosage. About 3 months later she was in the hospital for kidney failure. After 2 dialyses her kidneys returned to normal. BUT her kidney doctor said the cause of her kidney failure was Metformin, and she could NEVER take it again.
Ann
33844
When I was taking Metformin, I experienced muscle damage! Can you give me a feed back on that? LBK
william
las vegas,nv
I never had nightmares until I started taking metformin…will these nightmares go away after awhile..I’ve been taking metformin for two weeks now
Cynthia G
New Brunswick
I was just prescribed metformin and have yet to get the prescription filled. Reason being, I am a survivor of congestive heart failure and am on different medications, one being a pill for fluid and this is one of the medications mentioned as a threat in combination to the use of metformin.
I also have C.O.P.D. whereas I take 3 different inhalers numerous times throughout the day. The research I have found warns people like myself from taking the drug. I am not a diabetic, my doctor prescribed the drug merely to assist in weight loss. What is your advice in this matter?
Terry Graedon
It sounds like your qualms are appropriate. Metformin is not indicated as a weight loss drug, and if you are taking incompatible medicines, you should talk this over with your doctor another time.
Cheryl
I’m a 71-year-old female, healthy lifestyle and diet, weight problems starting age 45, eventually diagnosed with “insulin resistance,” “pre-diabetes,” and “metabolic syndrome.” About a year ago, my doc decided to start me on Metformin. About two weeks after the first dose, I experienced an increase in nightmares and then an unprecedented long terrifying night of waking/sleeping nightmares and severe paranoia — like nothing I’d ever before known. I notified my doctor and then completely stopped the Metformin. I’ve had no recurrence of the paranoia, the nightmares abated quickly, and I’ve added the drug to my list of “drugs that cause side effects for ME.”
I’ve been assured repeatedly that there’s no connection. I find a few random postings at different places that suggest otherwise. If docs don’t report those “unlikely” side effects, then they never make the list. Maybe they are unrelated — but I have no desire to be the guinea pig who finds out. So far, so good. I hope you resolve this.
Linda
BUCKINGHAMSHIRE
Some ten years ago or more, my Type 2 diabetic husband was prescribed Metformin and after taking it for just over six weeks was immediately taken off of it due to his having started an irregular heart beat. Nothing was ever confirmed that the Metformin drug caused this but he was not prescribed it again until about a year ago when his diabetic doctor said the drug had been improved and to try it again.
Against my better judgement, he agreed and just about three weeks ago he had a heart attack. I know in my heart and mind that it was caused by the use of Metformin. He has good kidney function, liver function and no Cholesterol whatsoever. It is telling everyone now over the internet that Metformin can cause men to have bad hearts and i know they are right. I have now stopped him taking this drug and have upped his insulin slightly, he has lost weight and is eating much better and his sugar levels are lower than when taking Metformin. The damage is probably done now but I hope this helps anyone wondering!!!
Sandra
virginia
Beware, not everything you hear is good about Metformin. As I read the comments, there are so many symptoms that I hear that are what I have experienced. Metformin was a nightmare for me and it messed me up good as to still keep giving. Only Doctor’s with special training and knowledge in Diabetes should be allowed to write a prescription for it. Not just a family doctor who over almost 2 months would not hear fully to the warning signs from MY BODY that it was having to the Metformin. Even shortness of breath and heart palpitations were dismissed as anxiety. A lot of Doctor’s do not need to be practicing medicine, PERIOD.
Tanya T.
Minnesota
I have just been put on Metformin for Polycystic Ovarian Syndrome. I started it this last Sunday, and now Tuesday I’m having very dry, cottony, metallic taste, hard to swallow, loss of appetite, and feeling more tired than usual. I haven’t been on it a week yet and I’m frustrated since I didn’t vwant to be on it in the first place since my parents couldn’t take it anymore because they were hospitalized due to side effects.
I have congenital heart defects, had 2 open heart surgeries, Congenital Heart Disease, Anemia, Fibromyalgia, Chronic Fatigue Syndrome, Social Anxiety with Panic Attacks, Scoliosis, Chondromalacia of the Patellas, Polycystic Ovarian Syndrome, and Arthritis. I questioned if I should really be in this drug given my health history and now I’m doing more research and thinkin it ain’t worth it and go back on my herbal supplements and be more religious about taking them since I had no side effects with them, but now I can hardly swallow my own spit, falling asleep while driving, and just don’t feel right. I don’t have diabetes, my glucose and a1c and blood pressure always normal.
Kris
96067
Similar to my own experience with Metformin, simply does not work with my chemistry. I get 9 out of 10, if you have any of these experiences, immediately cease using medication and contact your MD.
Well that as was perfect example of why only MD who truely understand these drugs should prescribe them.
I was told to come in for an appointment, I could barely walk, then I talked to the head nurse at the MD’s office, who suggested maybe I should go the emeregency room. Staff at the MD’s office were totall unprepared for the side effects of a product they insisted I take.
Kelly
I have been on Metformin 1000 mg daily for a year or so now. I have terrible restless legs and feet pain. I have been on several medications with little to no relief of my pain. The medications that I take for restless legs have caused me terrible side effects. Could Metformin be the cause. I am vitamin B12 deficient and do take 1000 mg daily.
cheryl
illinois
I have been on metformin for about six years. For most of those years I had all the classic stomach problems that goes along with this drug- especially diarrhea on a regular basis and stomach cramps. One day I saw a comment someone posted on taking probiotics for this problem. I went to the local Wal-Mart and bought the cheapest brand there and started taking one per day. I have not hand any stomach problems or diarrhea since. I hope this info helps someone else.
KWF
Ozark, MO
I have several similar experiences, especially gas and bloating. I also believe generics by different manufactures can be very different results, including signifant size tablets and density. I have read all comments regarding metformin and identify with several side effects. I just received CT test results and am concerned with results. Will call Dr. Tomorrow for full discussion of 2.6 cm cortical cyst upper pole right right kidney. parapelvic cyst versus dilated collecting system left kidney unchanged. I don’t know what unchanged means. CT shows other issues without explanation.
Maria
Indiana
About 16 years ago, I was prescribed Metformin for my type II diabetes, within a week I began experiencing nightly muscle cramps on the inside of both my thighs. On the third night I stopped taking the Metformin. Within a couple of days the cramps stopped. My Dr. insisted that muscle cramps were not a side effect of Metformin and upon my insistence changed my medication.
I found another physician.
In 2015 I was again prescribed Metformin and could not recall the issue I’d had because I had several drug allergies by then. On the fourth day of taking the Metformin I woke up with the worst muscle cramps on the inside of both my thighs and remembered why I had previously stopped taking it.
I stopped taking the drug and four nights later the cramps stopped. I immediately saw my physician and she said she’d never heard that before and that is was not on the Metformin side effect list. Older and wiser I informed her that she needed to report the side effect to the proper authorities and informed her that in the future an endocrinologist would manage my diabetes.
The following month, while in the endocrinologist’s waiting room, I overheard a another patient discussing her Metformin experience in detail. A few days after starting Metformin the muscles in her underarms cramped, believing she was having a heart attack her husband had her taken to the hospital by ambulance.
Several tests later, it was determined that she was experiencing a ‘rare’ side effect of Metformin and was taken off of the drug. Two days later the cramping stopped and she was released from the hospital. I doubt that the side effect is rare and find it upsetting that physicians dismiss patient concerns and drug side effect reporting. It is their job to monitor their patients reactions to drugs and report any problems.
Lynda
Connecticut
Maria – Thank you for sharing this! I have been having inner thigh cramps also! They are just horrible! I’ve been unable to identify a cause although I have been diligent in tracking what I was doing, eating, etc in the time period before they happen. Mine hit me at night while sleeping but during the day I can feel the muscles twitching. I think moving around, using the muscles during the day keeps them from going into a full cramp.
Even though I am prone to cramps in my calf muscles at night, the inner thigh muscle cramps have only started in the last year or so which is when I started taking metformin.
I can not express how different these two cramps are… the calf cramps, although painful, can be stopped in a minute by standing up and stretching out the muscle.
The inner thigh cramps are excruciating and can last for 20 or 30 minutes. If I move, try to stretch, it only makes it even more painful. I tried everything to prevent them and there didn’t seem to be any rhyme or reason as to the cause. I eventually found that heat from a heating pad is helpful but it has to be used preventatively so I now sleep with it on my inner thighs every night. I’ve still had two incidents of the cramping when using the heating pad but the heat seems to make it stop more quickly.
Other side effects I have that I believe are connected to the metformin are depression, anxiety, heart palpitations/rapid heart beat and general GI discomfort.
I was on 500mg 2x a day for about a year followed by 500mg 3x a day for the last year.
Danny
Fresno, California
Believe it or not, a couple teaspoons of pickle juice will make the cramps go away. I’ve been on Metformin 2 years for type 2 diabetes and suffer horrible cramps that make me leap out of bed hobbling with pain. Take the pickle juice and within moments/minutes, cramps are gone. My elderly parents – not on Metformin or diabetic – both swear by the pickle juice. I believe Apple Cider Vinegar is also helpful. The vinegar in pickles is likely the remedy.
Mary
I think I saw here that some used regular mustard for cramps. Worth a try?
Jane H
Salem Oregon
I am taking probiotics also, since going back on metformin recently — yogurt, kombucha, and probiotic beverages. It seems to help. And I make sure to include fiber in my diet. I’ve also seen comments that avoiding sugar, and other carbs, helps.
Austin
Australia
In October of 2014, I decided that it was time for me to take charge of my own health. I had tried several meds for Diabetes type 2 without success, and no way was I going to be a ‘lab rat’ for Big Pharma any more, so off I went on a journey of weight loss and dietary restriction.
By June of 2015, I had lost 20 kilograms, had dumped off junk food for the most part, and had gotten rid of high blood pressure, and cholesterol problems from my life. Some 7 months later, I have lost another 15 kilos, as weight loss seems easier now, having developed some good habits and also added several supplements to my diet in that time (I use Manuka honey, bee pollen – the natural grains, not the capsules, and take Metamuscil as a dietary digestion fix) and have exercised by walking daily, or riding my 3 wheeler bike morning and evening.
However, a recent visit to the hospital to treat an injury also showed my A1C levels had spiked to over 21!!! So the doctors put me on Metformin AP 6 weeks ago, but so far I have not noticed any side effects (500 mgs per day) and my DT2 symptoms have definitely disappeared.
So far, so good, but I’ll come back and let the board here know if any side effects occur. I’m in my mid fifties and have much better health than I did 18 months ago, and that’s why I finally realised that my journey was not just about weight loss, as that is only the first step along the way. It’s really all about lifestyle change, and that is what is giving me much better health.
However, the Metformin is still an unknown factor, so I’ll be keeping a steady eye on its performance… no more la brats at my place… :)
Loretta
Illinois
I think I need a second opinion. I was given these meds based on a test two weeks after lab-work.
No problems with blood sugar prior too. I have had chills, stomach problems and at times very tired. My fasting blood sugar has never been over 106. I think my doctor made a mistake. Blood sugar were 88, 91, 90, 83. I had an A1C of 6.5.
Char
I started with metformin several years ago. I first noticed I wasn’t hungry which was good but then found myself having to force myself to eat. Then the stomach problems started. I could hardly make it to the bathroom in time! I was constantly have cramps, diarrhea, and lose of appetite. All I could stomach was rice! I talked with my doctor and he said to cut back the dose for a week then restart. I finally had to start seeing a new doctor because my former doctor told that the metformin was not causing my problems. It’s funny because I didn’t have problems before metformin and they stopped as soon as I quick taking them.
Stephan S
Wheeling WV
Took metformin fora couple of years before any problems developed. Then bathroom 4 to 5 times a day, lost 40 pounds. Found out that I needed digestive enzymes, lipase, protease and amylase. Was like flipping a switch. Digestive issues went away almost with the first dose. Have gained weight, not too much. Bathroom once a day or less sometimes.
Barb
Florida
Your story is exactly my current situation. Even the 6.5 A1c. Have not picked up the Metformin yet. How are you at this time 3-14-2017?
Tom
Cleveland, Ohio
An A1C of 6.5% is Diabetes!! Your blood sugars are changing throughout the day. You can’t just look at Fasting Blood Sugars.
Frank Lucas
US
I started metformin in November of ’97. I had some stomach uneasiness for a few week, which went away. The pill I was taking was a big, white chalky pill two twice a day. I was put on Janumet about four years ago (circa 2011), with no noticeable side effect. I was receiving Janumet through Patient Assistance. The manufacturer stopped the assistance in June of 2015, so I was prescribed metformin, again. These pills were similar to an aspirin but slightly larger. Over the next five months, I developed every side effect of metformin. I visited a GI specialist who told me that the results of five tests he had the hospital lab perform came back negative. He had reviewed my hospital record and suggested that I stop metformin. A week later, the nightmare was over. Was it metformin or a change in manufacturer?
Angie
St. Louis, MO
I have been on metformin since I was diagnosed several years ago. About a year ago, my neuropathy became debilitating. Just going to the store for maybe an hour kept me off my feet for 2 days. I have had my B-12 levels checked periodically and they were normal. After reading info on this site about metformin and B-12 deficiency, I talked to my podiatrist. He suggested a B-Complex. I have been on it for about 2 weeks and the difference is amazing. My feet hardly hurt at all, I can bend my toes more that I have been able to in a long time and I think I am getting a little feeling back in areas that are numb. I have suffered terribly for a year because doctors prescribe medicines without really knowing the side effects. Metformin and B-complex need to be prescribed and taken together. Doctors NEED to know this! Now I’m going to talk to my doctor about the gas and bloating…..to be continued.
J. David Auner
Springfield, MO, USA
The elderly are usually a special group. In the case of metformin, the life threatening adverse reaction of lactic acidosis occurs almost exclusively in excessive doses and with declining renal function. Most of the diabetes experts I queried 10 years ago did not have any patients over 70 on metformin. Yearly renal function testing is likely to be inadequate to protect people over 70, those with intercurrent illnesses and with the addition of any new chronic and some short term medications. Diabetics over 70 are, in my experience, fairly likely to suffer declines in their renal function.
La Donna
Nebraska
I take 250mgs. of metformin in the morning. I always have a stomach ache all day except
feel better in the evening. I don’t know if it could be the metformin or what. I watch what
I eat and drink only water. Does anyone have any ideas on this subject? I quit taking the
metformin for awhile but still had stomach aches. Could it possibly take a few days for
the metformin to get out of my system. I also have burning pains in my arms and stomach.
Carole
Sydney, NSW Australia
You didn’t mention Metformin as a PRO-pregnancy drug. Seems to do something for PCOS and to work like a ketogenic diet for low fertility. This was first noted about 10 years ago. I printed out the info then and gave it to a woman wanting to get pregnant Non-Diabetic and now I have a baby named after me!
Gloria
Durham NC
When I started Metformin many years ago, I had stomach pain. Only thing found on UGI was minimal reflux. Zantac was prescribed, and my stomach pain went away. Now that I am now on generic for Zantac I do have some stomach pain but not as much as before.
george
home
here
JIM
CENTRAL NY
Been taking metformin since 2010, when the doctors office did a ‘whoops’ and gave me diabetes. So much for medical records, only good if the doctors read them.
The side effects were bad for a while, but in using research from the Peoples Pharmacy and other sources, found my main problem was Generic metformin. My uncle, who is a Swiss doctor told me NEVER use generics. Now on the real Glucophage and almost all of the side effects are gone. My numbers have dropped and not having the foot problems anymore. Drugs effect people differently.
SUSAN
Cleveland, OH
Jim, I had the same experience as you did. Metformin made me terribly nauseated, so I did some research which pointed toward Glucophage not causing any side effects. Long story short, after arguing back and forth with my PCP who stated there was no difference between metformin and Glucophage, he finally agreed to prescribe Glucophage. I’ve been on it for two months, and I’ve had NO adverse side effects. My A1C dropped from 8.7 to 6.8 in these two months, and I feel so much better.
Mary
Susan,
Read my comment about Dr Richard Bernstein, (diabetologist supreme) recommending taking ONLY the brand name drug!
Robyn
Central VA
I have chronic Lyme disease, which has messed up many things for me, including raising my A1C levels. Medical science is beginning to think that diabetes, and many other diseases, is caused by inflammation. Do what you can to lower your body’s overall inflammation load. Also read about non prescription ideas such as juicing bitter melon (found at Asian grocery stores and occasionally, Whole Foods) to lower your sugar levels. I found this to be very effective. Make sure you tell your doctor about any changes you make. Regular doctors will probably balk at the idea of bitter melon, but find an integrative or functional medicine doctor who will support you.
bella
ecuador
I live here in Ecuador even though I’m english speaking, after being told I am diabetec with stage 2, I started taking Metaformin 500mg. Wow to me it was too much went through a lot of pain in my liver stomach heart and kidneys, felt like throwing up, my feet hurt even more than before, so I started taking half a tablet of the 500mg but I still go through this pain I dont know why can someone please tell me.
abbey
canada
I have been on metformin for about 16 years or so, for the past year I’ve had Uti infections….at first the dr refused to admit something was wrong…..I’ve tried EVERYTGHING….I am wondering now if its metformin that has messed things up it’s the only link here….(i’m not telling people who need this med not to take it, (I’m not diabetic I have pcos) I’m saying READ up on it before taking it! side effect might out weigh EVERYTHING eles and it might not be right for you (you know when you see the ads on tv and the side effects are worse then what the goods are) be very careful with what you take…(the dr did a scan of my kidneys and never called back so I assume things are ok.
Mary
Abbey,
I would ask my doctor for the written results of the tests taken. Don’t be in the dark.
Dinty
Central Connecticut
I’ve been metformin for a month and sugar readings are better. However, I started taking Cinnamon Bark oil which reportedly lowers blood sugar. Goal is to get off the Met.
Anne
NE
I have just worked up to 1500mg a day of Metformin xr.
Everything was fine at 1000mg, but this last 500 is causing side effects… stomach hurting and acid reflux. I am going to hang in here for a week, before I go back to 1000. I really want to give it a chance.
John
Ohio
I think I’m an unusual type 2. I’m 71 yo, with an A1c of 8.4. I’m a competitive runner, very active, 5-10, 159 lbs, perfect health (except the A1c), don’t take ANY prescription meds, and I eat carefully I probably drink too much, 2-3 beers a day, but it’s all light beer with low carbs.
No matter how hard I work out/run I can’t seem to get the A1c under control. In fact, after a hard run (5K, 28:00) my blood sugar spikes to 200-225.
All diabetes diets start off telling you to get more active and lose weight. That clearly isn’t what I need.
Any thoughts or observations would be greatly appreciated. Thanks!
HelenM
Modesto, CA
Don’t know if you set yourself up to receive replies: you might have type 1 diabetes, treated only with insulin. Your age does not make it impossible. There is a variant of type 1 that affects adults. Initials are LADA, latent autoimmune diabetes in adults, and it has a much slower onset than type 1 diabetes in youths. There is a test they can do for certain anti-bodies (GAD) which can confirm this. Type 1 diabetics usually do not have the weight issues of type 2. While it is not associated with metabolic syndrome, you can have the same kind of complications. For your health’s sake, I would suggest a more aggressive follow up of this problem; hopefully with an endocrinologist, or a diabetologist, if you can find one.
Marty
Glencoe, iL
Hi john
Wow I have just received my first a1c report 8.4
I was diagnosed with type 2
I also exercise daily. 500-750 laps on pool daily. Walks up to 15 mikes. Weigh 188 5’10. I was told its biological. What have you heard?
Regards Marty
May
Gresham, OR
My doc recently prescribed Metformin for Type II diabetes, and I was very pleased when the blood sugar was better controlled than it had been.
Fortunately, though, she had ordered lab work as she does on a regular basis. It showed that my potassium level was too high. She had me stop taking the Metformin & a blood pressure med that contains potassium, and it got back to normal. I shudder to think what could have happened without that lab work. And I’m glad my doc realized what had caused the increase in potassium.
Devon
New York
All I can say is that I sympathize and was having similar issues even on Bydureon weekly injections and the once daily Invokana pill (100mgs to start for a month). I was having terrible trouble with the dawn phenomenon–fasting blood sugars going up to 180 occasionally, and I wasn’t eating more than 30 carbs a day.
I decided to add Metformin even though I know I can’t tolerate the gas and bloating–and feeling PREGNANT, which you may not experience. GRIN! BUT—my blood sugars have stayed between 90 and 95 ever since. I am, however, absolutely miserable from bloating as soon as I take the pill (only 500 mgs). I have started taking it at night so I will swell up when no one will see me.
I am calling my doctor tomorrow about starting the XR variety instead. I can attest that your A1C will certainly go down as it sounds that you, like me, may have a liver that is throwing too much sugar into your system regardless of what you eat. Metformin counters that effect beautifully. BUT OH THE TUMMY woes….
Good luck!
N1
Some steroids can raise blood sugar.
Elisha M.
Hamlet, North Carolina
I have been taking metformin now for almost two full years. I started out with my blood sugar spiking up to 890. I have been in the hospital twice for blood sugar spikes. My a1c at its height was a 10 got it down gradually to a 7.2 as well my weight dropped from 245 lbs to 185 lbs. I feel as though my eating habits, faith and fear directly contributed to the weight loss and the lowered a1c. I have to take this with more severity though my weight has gone back up to 210 lbs I think my a1c has climbed back up to 8. So I’m looking back in order to move forward my eating habits were mainly raisin bran cereal with no high fructose corn syrup, salads with lots of grilled chicken without dressing. See you all on the healthy side.
Susan
NC
I have taken Metformin for many years now for Type 2 diabetes. It only seems to bother my stomach if I run our for a few days and then start back up. It did not help me lose any weight. I now have stage III colon cancer, so Metformin obviously did not keep me from getting cancer. I have also been diagnosed with Wolff-Parkinson-White syndrome, which causes rapid heart beat. After reading this article, I am wondering if the rapid heart beat is from the metformin and I don’t have WPW.
TONY
SHERIDAN, OREFON
I have had type 2 since may of 2011 and metformin made me sicker than a dog!!!
I went to a naturopath and began a regimen of supplements in addition to the vitamins and other herbs I was already taking!!!
The average monthly blood sugar dropped from 178 (monthly average taken once a day) to 130 and it continued to drop!!!
For over a year now it has been under 100… I had to change doctors because of medicare requirements to get testing supplies, but I still maintain the supplements!!!
I saw him today for my quarterly check up and he is well pleased and predicted I would live past the century mark!!!
He is a whole food nut and touts fish so much that I think he has a kentucky fried squid franchise on the side!!!
Helen M
Modesto, CA
There are specific ways with which to begin metformin. Slow and slower for one! At the back end of your largest meal for another. That will usually eliminate most of the GI problems. So – you take 500mg after completing your largest meal. If you tolerate this, you begin to move the met thru your meal until you are taking it before you eat. I have read for maximum effect upon post meal numbers, it is best to take it a half hour before eating. I never remember. Then you do the same with your next largest meal. Some people see results on only a gram a day. Most people need more. Your options are to add an additional 500mg, same way until you are taking it before your meal. Then assess, do you need more? When do you want to take it?
There are people who never adjust; they should try the timed release before giving up on the drug. It has a lot of benefits.
As to kidney issues: Research has shown that people with impaired kidney function can do well with metformin too. However, the dose is related to the eGFR. I have one kidney, eGFR 53, started metformin two months ago. I am up to 1500mg a day, will have kidney tests next week. I took metformin for many years until I was diagnosed with cancer in both kidneys. My endo immediately removed the met and I had to increase my insulin by 50% and, once again, experienced problems with constipation. A lifelong condition that responded well to the met. This time that has not been true; however, I am taking more drugs with constipation as a side effect than I was the last time I was on met. More anti metabolic drugs too and I have not seen the decrease in insulin usage that I was hoping for. However, as a type 2 diabetic, diagnosed in 1983, I use very little insulin a day, about 21 units, and perhaps a further decrease, without changing other lifestyle factors, was not possible.
Abigail
NW
There are several brands of Metformin. I switched to Amneal brand because the brand available through my HMO made me feel ill.
Ladyliza
Los Angeles, CA
Dear Helen,
I am on 1000mg metformin/day, and it does nothing for me. Can you please tell me what you are taking and the dosage? Also the brand. Many thanks.
Mary
Dr. Richard K Bernstein, an 81-year old Type 1 diabetic, says to use the original glucophage and not the generics. He questions their effectiveness.
And DO supplement with B12 or possibly along with all B vitamins. I have read that B1 deficiency is common with diabetes.
Methylcobalamin is the most easily absorbed form of B12 per what I have seen online.
Pat
Dallas, TX
I had been on Metformin since March 2010. I lost 20 lbs. in less than two months after starting the medication. It took a year for the next 10 lbs. It controlled my sugar up until May of this year. Having suffered with food allergies for over 30 years, I wasn’t surprised when my body started rejecting the Metformin. A pharmacist told me he was really surprised I couldn’t take it. He says doctors are prescribing it as a anti-aging pill today.
Sylvia
Waco, TX
I gave taken Glucophage/Metformin for 12 years with great results. I tolerate it well, and my A1C is 6.0. I do take the extended release version of the drug, have lab work twice per year, maintain a healthy weight, and exercise daily.
Elisabeth Meijer
Australia
I experienced severe diarrhoea when on Metformin. At my request my doctor switched me to the extended release tablets and I no longer have diarrhoea.
Many people have reported muscle pain, fatigue and memory loss as a side effect of Metformin. A number of prescription medications rob the body of CoQ10, and Metformin is one of them. Low levels of CoQ10 cause muscle pain, fatigue and memory loss. Consider taking CoQ10 capsules.
Ann
United States
I have been taking Metformin about a year. 500 mg. (1/2 in A.M. and 1/2 P.M. with meals. Drink a ton of water. Since then I have quickly lost about 63 lbs. My sugar is very controlled. I really like Metformin. I do have alot of diarrhea but had that before the drug. Seems like everyone has a different experience with it.
Tina
United States
I am not diabetic, but just suddenly stopped losing weight after changing my diet and becoming very active. I was put on glucophage about a week ago. I had some mild nausea the first 2 days, but I am experiencing a lot of gas and heartburn. I feel very bloated, and I am taking tums throughout the day
Louis
San Francisco
I have been taking Metformin for a year now. Instead of declining, my sugar level rose from 150 to over 300 in a year, despite life style and dietary changes . After I take the medication, my blood pressure goes up to above 150 (Sys) and between 95 and 100 (DIA). I was better off without this drug.
Carrie
CT
I have been on 1000mg of metformin for about 6 mths. I experience severe gas and rumbling in my stomach. The amount of gas by flatulence and burping is alarming. Sometimes my stools are complete water and gas. I’m getting concerned.
DJ
Are you taking the full 1000mg at one time per day? You could try splitting it up morning and night. I find that if I take it on an empty stomach, even if I eat enough after, I eventually end up with the watery stools. I try to take it in the middle of my meal. Also – I find that I have less stomach upset on the regular version which is opposite most that tolerate the ER version better. If you are on regular – ask your dr if you can switch to the extended release. For me there is something about the ER coverings of the medicine that bother my stomach more.
HTH
JRATT
Great Falls, MT
Just diagnosed with EDEMA, taking 25 mg hydrochlorothiazide and told by Dr. to cut out salt and lose weight. Found a great book Protein Power – eating high protein low carb and have lost 18 pounds in 30 days. High carb low fat diet keeps insulin levels high and causes weight gain. Insulin is the fat storage hormone, lowering insulin levels through diet helps with weight and decreases insulin resistance.
Mindy
California
I am newly diagnosed and put on Met. I thought I had the flu! I am so sick. I can’t go out for the diarrhea, I am totally nauseated, my back aches where my kidneys are, and I am hot and sweaty. I’m trying to diet and even though I can barely eat I’ve gained 4 lbs back of my 46 Lb loss. I read the side effects of this drug and I already suffer from : Depression, shallow breathing, and racing heart. Why would they put me on something like this my anti depressant already makes my stomach sick. They have never called me back today, the office is now closed. I am concerned the other drugs out there are not as safe as this and I’m not handling this!
Dianna A.
United States
I have type 2 diabetes. I have been taking Metformin for 5 years. My doctor has increased dosage to 500mg three times a day. In the last year when I get to hot either playing golf or walking my dog my bp drops very low. I get really dizzy, heart beat increases and very weak. I have to sprinkle salt in my hand and eat it to get my bp back up. I also have days of severe diarrhea. I’m starting to adjust my dosage on days I very activity. I hope it helps.
Don
Texas
I started out @ 2 doses of 500mg per day on metformin, then the doctor went to 3 times per day…in the beginning I had all the symptoms listed, & I asked & received doctor approval to break the pills in half, just keep up the dosage. I eventually became more tolerant of the drug, but exercise, diet are very critical to absorbing the pills properly. Finally I am at a point where I reasonably keep my sugar levels under control, most symptoms have been minimized.
geraldine
Upstate New York
Have been on Metformin500mg for abt. 10 days . My blood pressure has dropped at least 20 points, and puts me in the low blood pressure range, and feel a little dizzy. Stay home until after lunch, then feel better.. Take Metformin with a meal. Will call my doctor on Monday (April 20th) This drop in bp is odd because I have a difficult time with my high blood pressure. Am on 3 meds for high blood pressure. Any one else have this reaction to Metformin? geraldine
karl constantino
Bethlehem, PA
Terrible diarrhea. Insulin therapy is welcome
karl constantino
Bethlehem, PA
I’ve had such bad diarrhea that insulin sounds sweet
Valerie
Edmonton, Alberta; Canada
My mother had started taking Glucophage metformin in the mid 1990’s. In the summer of 2004, she phoned me, crying in pain, and saying that she was unable to walk. She rubbed her shins as she cried and told me she hurt there. I drove her to the hospital. To make a long story short, metformin destroyed her kidneys because she didn’t try to diet and lose weight. she liked snacking on sour cream with brown sugar, white bread, and KFC at least every now and then. I feel that because she didn’t work with the Glucophage metformin, it worked against her. My mother then started peritoneal dialysis, then several months later, was on hemodialysis. She passed away April 13, 2010.
Sabrina
San Diego
A friend of mine told me that Metformin has caused significant hair loss for him. I have noticed too since I started taking it. I found nothing on your web site about it so I did a search and found this
“One possible side effect of taking a medication called Metformin is hair loss. In fact, it is sometimes prescribed by doctors to treat patients suffering from a medical condition called hirsutism. This causes excessive hair growth and is often one of the unpleasant symptoms of PCOS or polycystic ovary syndrome.” http://www.metforminfaq.com/does-metformin-cause-hair-loss/
lin
Extended release metformin eliminated stomach pains and diarrhea symptoms. Please try this before other less safe meds.
Habiba
Egypt
I’m not I diabetic , but I take metaformin for weight loss but not under a doctor supervision , I almost have all the side effects written above , but it really helps in controlling my appetite but I suffer conistently from nausea , is there any suggestions ?
Paul
I want to stop taking Metformin because of many issues others have described; I, too, have similar complaints; my concern is “going cold turkey,” so to speak and the health implications that may occur–I am one with Diabetes 2. I’d like some answers from those who have given up this toxic drug.
Paul
Texas
I’ve had problems that I believe are related to Metformin–severe digestive ones–watery stool, stomach pain, and a bloating sensation; the doctor I have doesn’t seem to believe my distress; I need to take a substitute for Metformin–a natural one–because I am determined as one with Diabetes 2 to stop taking this drug; I need to know of a natural substitute as I begin to go “cold turkey” with Metformin. Thanks.
Diane
Paul, it sounds like you’re looking for berberine, a natural alternative to metformin. Studies have shown it to be as effective as metformin, but without the side effects. There is a very informative article written by Dr. Jonathan V. Wright, MD. It is found at http://www.tahomaclinicblog.com/berberine-diabetes/
My mother has type 2 diabetes and was on metformin. We worked with her doctor to replace the metformin with berberine. He’d never heard of it, but from the articles I gave him, he decided to let her use it. He became a believer in berberine.
We chose Glycosolve (berberine 500mg) because it’s made in the US and guaranteed to be pure. We found the lowest price at Amazon (Leaner Living store). It’s best to take it 15 minutes before a meal. Diet is still important in being successful with this. Since your doctor has been unsympathetic to your metformin side effects, you will probably need to ‘educate’ him by giving him a copy of the above article. If he is still unwilling to work with you on this, then you have a doctor who is in disharmony with your health. There are better doctors available.
Cee
Upstate, SC
Organic Apple Cider vinegar with the “mother” in it will help. Instructions are on the bottle distributed by Bragg
Carolyn White
Ben Wheeler, TX
My husband has been on metformin for 6 years. And now he has renal cell carcinoma.
Ms.Malone
My, OBGYN prescribed me metformin because I was recently dx with pcos, which I don’t understand because my doc. didn’t really explain to me all he was thinking about my weight. I told him over an over it’s not my freaking fault- I can eat once daily, and not so much at that, and I will still gain 2 lbs. This is stressing me out taking out my hair I was once very beautiful my looks change hair growing on my chin I don’t have a family and would like to have one on my own. My OB told me to take 1500mg of metformin once daily and he said soon I will be pregnant, which is unbelievable! So hopefully this metformin helps me…
Elsie
Puerto Rico
My husband has been taking Metformin for about ten years, and after reading all of these comments I am worried, because he only has one kidney.
Ralph
Chicago
I have type 2 diabetes. Have taken metformin for 6 yrs. Was just released from the hospital after suffering from acute renal failure. My creatinine levels were at 5.7. I was taken off metformin and my numbers have come down. I also went to see a urologist during this time. After tests I am now beginning my fight with bladder cancer. I have become very anti-metformin. My blood, liver, and kidney functions were tested every 3 months. All were OK, then all of the above happened in a very short time.
Julie
Nevada
Eating only once a day is the worse thing you can do for your body. You need to eat at least 3 times (if not 5 times) a day. The thing to do is to think of them not as meals, but as snacks. Eat fruits and veggies, but also don’t forget to eat some kind of protein. Just keep is to small portions.
Alison
Ask your Dr to do an Insulin Resistance blood test
Corryn
Victoria
Hey my name is Corryn and I have been taking mediformin for 6 months haven’t had much problem with it until I went up to 2000g a day. I have had a headache for 4 week now and I want to know will this go away or will I have to stop it ??
Lupe
San Antonio, Tx
I have been taking Metformin for about the same amount of time.. my symptoms were very loose bowels, headaches, stomach pains.. but recently those symptoms almost gone.. loose bowels occasionally.. but not everyday all day.. headaches.. once in a while.. talk to your doctor.. maybe dose too strong.. best of luck!
Rosa
Tx
Is it bad to stop metformin ? I have to many side effects.
Rosa
Tx
Glucophage causes me to cough all the time it does not stop, stomach pain, I’ve gone to Dr. for cough, taken medicine for it, does not work, when I stop taking glucophage my cough stops.
Najal Sabir
Dallas
I have been diagnosed with diabetes 2 and have been taking metformin for almost two and a half months and I have not experienced any of these symptoms. I have lost 15 pounds which I needed to before I was constipated headache dry mouth, urinating constantly every time I was out and about was going every 30 minutes now all that have disappeared I take my medication at night. I exercise 30 minutes a day change my diet to mainly vegetables and protein and I feel great have a lot of energy. Before than didn’t.
Katrina H.
United States
I was prescribed metformin for weight loss because I take an antipsychotic and it causes extreme hunger. I was excited after my first dose, my hunger went way down. I could look in the fridge and not even take anything! But I knew it was too good to be true, because it gave me severe bladder pain! I will not be able to continue this drug. I already have bladder issues (IC), and the metformin is really flaring up my bladder pain.
Katrina H
United States
I was prescribed metformin for weight loss because I take an antipsychotic and it causes extreme hunger. I was excited after my first dose, my hunger went way down. I could look in the fridge and not even take anything! But I knew it was too good to be true, because it gave me severe bladder pain! I will not be able to continue this drug. I already have bladder issues (IC), and the metformin is really flaring up my bladder pain.
nilly
tanzania
It has been 2 weeks since I have taken this medicine. I get severe stomach cramps similar to labour pains. is this normal?
Bella
RI
Try lactase enzymes. Any brand like lactaid
Bella
USA
I find if I take lactase enzymes when I take my Metformin (I’m not lactose sensitive at all) it has made the side effects of the Metformin, neutral. No specific brand, I just buy lactase enzymes suggested by a nutritionist. And it works for me.
Kesha
chattanooga
That sounded like an commercial for metformin.
Sue H.
Florida
I’m glad I found this site. My FEET ARE BURNING!!!! I thought it was athletes foot, no. I’m in so much PAIN!!! I can’t sleep, I wake up every hour on the hour. The only way to stop the burning and sleep for about 3-4 hours is to soak my feet in ice water. Yes a pan of ice water for 15 minutes. Then go straight go bed. My a1c was 5.9 last time at the endocrine doctor. I go there for thyroid not diabetes!!! So why did they give me the metformin??? I am at 260lbs now due to the thyroid and YES I follow a low carb diet and walk daily. I want to thank everyone for their shared comments. I will stop the metformin and get some B12 back into my system too. Thank you and God Bless!!!!!
ILN
I have been on Metformin Long for exactly 1 year now, taking 500×2 twice a day. Reason: high blood sugar levels (12.9), excessive weight (138 kilos) and high blood pressure (190/110). In the course of the past 12 months I lost 45 kilos of weight, blood sugar reduced to 4.3, blood pressure approx. 120/80. I reduced me eating habits considerably, but do not exercise.
Needless to say, I feel much better now. No nausea, diarrhea, weakness, etc. The only thing that worries me are occasional constipation. Something that I never experienced before. Anybody experienced anything similar?
MFM
Silicon Valley, CA
I was diagnosed with Type 2 diabetes in January 2014 with A1c of 7. Primary Doctor put me on Metformin in late March and within 6 weeks I experienced constipation regularly before breakfast (usual morning bowel was soft) and this problem was irritating my hemorrhoids.
After realizing the cause being from taking Metformin (500mg after dinner daily). I tried Colace without success; then, I tried generic stool softener with 8.9mg of laxative without success. Now, I drink 16-20oz of water just before going to bed (an hour before bedtime) and have found stool to be between medium hardness to firm (but does not irritate my hemorrhoids). I don’t mind waking up several times a night to urinate because I can fall asleep quickly each time. This may be a caveat for anyone who struggles to go back to sleep. So far, I don’t seem to experience constipation during the day and I may drink less than 30oz of water.
I hope this helps someone with constipation and add his/her success or failure to their search question.
B.R
I was diagnosed 1 year ago with type 2 diabetes and I was put onto 2000 mg per day of Metformin. Now I can come off of it but I declined but I’m in 1000mg per day for 3 months then get a HBA1c done then hopefully come off the drug. I’ve noticed a lot of hair thinning.
jonathan c
I am a diabetic for 20 years on insulin and metforman 1000. I’m having excessive flatulence and berb gasses and heavy constipation. Can metformin be the cause?
angel l.
I have been taking metformin for months now, but lately I have severe aches all over my body, not only that I am burning from the inside and I feel blisters forming, I stopped, but is there anything I can do?
RG
I’ve had diabetes 2 for over ten years now and have been on insulin for 4 years. Since I was put on metformin I have been having diarrhea and I complained to my endocrinologist and he said its the best tab for me. And he said that its probably taking out lots of excess sugar in the stool that it helps control the diabetes for me. But it scares me when I am outside and I have to find a toilet and I have been worried that accidents might happen while trying to find one. Times when I didn’t even want to go out, or sometimes i go out with my grandkids and it is very inconvenient to run looking for a rest room. I go out with friends and I have to find a place two or three times, its embarrassing. Is there any other tablet without that side effect?
JimG
Maryland
My very sweet PCP at the VA (Note:sarcasm) looked and spoke at me like I’m an idiot when I complained about explosive diarrhea from my metformin and snorted, “Take it 30 minutes after your meal.” What do you know? It works! No more diarrhea! I just won’t mention to him how thankful I am for the answer. It may not work for everyone’s system but it sure works for mine. Now I’m going to experiment taking it 30 minutes BEFORE my meal and see if it does a better job controlling my glucose while (hopefully) avoiding the diarrhea.
PV
I was placed on 500mg of Metformin for Type II diabetes. My A1C has never been higher than 6.0. After taking the Metformin for a year I developed weakness in my legs, bone pain in my hips and severe diarrhea. I stopped taking the Metformin and these problems went away. I resumed the Metformin and the problems returned. I don’t care what any doctor tells me, any medication that makes your problem bigger can’t be good. I believe the risks outweigh the benefits.
Lisa
Ny
Yes! I am a type 2 diabetic and have been on it for a month and a half possibly two months now and at first I lost a bunch of weight and felt pretty darn great. Next thing I know my appetite increased and all sorts of other things started to happen. Terrible Numbness in hands and feet, dizziness, tiredness, fatigue, light headed, weight gain, Nassau, headaches, Blurred vision, shakiness, and now my legs feel weak. Along with other things. Iv’e decided to contact multiple physicians now. I want to know what they have to say. (Dosage: 500 mlgs 2x a day) I am also on victoza 1x day.
Sue C.
After only 3 months of er metformin the muscle aches were so bad could not function was hospitalised so much pain couldn’t use my hands. It felt like I had been kicked all over. I’m off them now. So far for just 2 weeks still got muscle problem but think it will take a while to go back to normal.
Kelly K.
I just started taking 500 mg of metformin once a day this past week. I am also a heart failure patient. My cardiologist said it was ok to try this medicine. I am not so sure. My A1C was 8.1 in march, down from 9 last year at this time. Anyone else on this that’s a heart failure patient?
RP
PH
This article might be relevant for you.
http://www.diabetesselfmanagement.com/Blog/Diane-Fennell/metformin-affects-hearts-of-men-and-women-differently/#.VGdus_fE0jo.facebook
Donna
I have been taking Metformin for 20 yrs now and the worst side effect I got was Gerd. I take prescription vitamin B12 and one weekly vitamin D for my kidneys because I went into renal failure because of the Metformin. I still take it but at a lower dose and the vitamins help.
May
I am a T2 diabetic patient and had been on metformin, 500mg, morning and evening, for about 3 years (just stopped the usage). I noticed that the more I use it ,the more my muscles relaxed and sagged even with 1hr (at times 2hrs, morning and evening when I had time). My muscles and skin were no more firm and I started looking much older than my age even with my serious routine exercise!I stopped for about 3wks now and have been on a very low carb (veg and protein) diet. My muscles are now much firmer and am looking younger that is very noticeable! I am worried now about the effect of much protein on my kidney in future! Thanks. May.
mari
My husband has type 2 diabetes, and has been on 20mg glycide per day plus 1000 mg of metformin per day. His kidney function has dropped to stage 3 kidney failure. His Dr has taken him off the metformin, but has not replaced it with anything else. Can anyone recommend another medication so we can ask the Dr. about it. The glycide alone is not keeping his BS down. Insulin injections would affect his job, so we are trying to avoid this.
Sly
I have type 2 diabetes and was diagnosed a year ago. Ever since I have been on metformin 500 mg three times a day. For over six months my stool has been light green. Every thing else is normal. Are these light green stools caused by metformin?
Peter
California
Look into berberine. Natural from the herb food store. Works great to lower bloodsugar.
Alan
I have been taking Metformin 500MG for a year for my diabetes T2. It appears now that it is causing me low blood pressure so I have been advised to reduce the dosage to half a day for the next month. Anyone have similar problems?
E.L.
I’m on my fourth day of Metformin 500mg once a day. I immediately noticed lower back pain, mostly down through my buttocks and my left leg. The pain is like an ache, feels as if I have pulled a muscle. Today I was able to definitely associate the Metforminn with the pain. The pain occurred within an hour of taking the metformin. Am also noticing a burning sensation on the bottom of my feet. I was hoping that these side effects would go away after a short time on metformin, but after reading the comments on this forum, have serious doubts. My A1c has never been higher than 6.1 but I was gaining weight like crazy and feeling very sluggish/extremely tired and my iron and vitamin D levels continuously low so I requested to be put on metformin. I now wonder if I will be able to continue with this medication?
KH
I’ve been taking a very low dose of metformin for a little over a month now. It never seems to bother me of I take it with the biggest meal of my day. But if I don’t have enough food with it, the diarrhea is so severe I’m scared to leave the house. :/
Marie
I am on metformin for months now and noticed low back pain, buttocks thigh to the leg pain, just wandering if metformin is causing it, I have seen ortho, physical therapist, acupuncturist, massage therapist and Chiro but still suffering from severe pain anyone with same problem?
Chris
NYC
Hi Marie
same here wondered if it was the heel spur that didnt heal. But believe the medication is the cause. I take alot of yoga and it helps ease the pain. A foam roller is helpful as well.
I also have been experiencing memory issues…
be well…
x
Susan
I have been on Metformin for 3 years now and I have constant diarrhea, it has gotten so bad that I am having absorption issues. My vitamin D levels are very very low (22.3) when normal range is 30.0 – 100.0.
I have been complaining to my doctor about this but it seems to go in one ear and out the other with him. I know time to find a new doctor!! I did not want to stop the metformin as it seems to be the best med out there for type II diabetes. Is there any other drug that works as well as Metformin? Worst part is I have not lost any weight, at least that would have been a bonus!
Helen
I am wondering if Glucophage can increase anxiety.
People’s Pharmacy response: this is not a common reaction to metformin.
Giselle
Lake Charles
Helen, it may not be a normal side effect, but I just took my first dose today and about an hour later had an anxiety attack. There is no way I’m going to take this stuff. Those attacks are horrible. Still going through it now, I hope it goes away soon.
lana
I’ve been taking Metformin for about 2 years and during that time Ive lost a few pounds. I also feel tired after about 2 hours. At first I couldn’t figure out why I was so tired all the time and then I noticed that it was only after I took this medication. Since that time my doctor has placed me on the slow release version of the medication. But my big issue now is heartburn. I’ve have been experiencing this terrible heartburn to the point that I feel like I need to go to the ER if I don’t get any type of relief. I believe that it maybe one of the side effects. I have to do some more research and see what happens.
Has anyone heard about any heartburn side effects??
stephanie
I was diagnosed with pcos 3 years, few months later I was diagnosed with pylonepritis and was treated with gentamicin, but I still felt symptoms of pylonepritis and my doctor said my kidney was still patchy even after the treatment. She advised I should take plenty of water. I have been trying to achieve pregnancy and I was placed on metformin 1500mg, please will metformin have any effect on my kidneys even with pylonephritis? I still feel pain in my flank and abdominal discomfort and bloating. Thanks.
kathy
I took four doses of Metformin over the course of 2 1/2 days and then developed excruciating pain while out walking to the point that I felt like I might not be able to get home. It was in my lower back and up thighs. (I’m 55 and walk regularly.) I did a google search and found others who stopped after developing pain. Has anyone on here?
Dot
Metformin has caused my husband to lose weight and his appetite. He is nothing but skin and bones from it. He has stopped taking it as of yesterday.
He has type 2 diabetes.
Daisy
Metformin caused me increasingly severe diarrhea, to the point where I was having a dozen or more episodes a day, and lost 14 pounds in two weeks. I had been on Fortamet, but asked to be switched to generic metformin because of the cost. I also had daily diarrhea with Fortamet, but it was much, much worse when I took the generic form. I’m now on a slow-release form of Fortamet, but still have two or three bouts of diarrhea almost every day.
DBK
Metformin has taken some time to get used to. At first, with a twice daily dose, it caused sudden diarrhea that was inhibiting my daily life. I am now on once-a-day insulin and take a low dose of metformin(1/2 tablet or one whole) only at night. I skip a dose if I know I have a morning appointment because the sudden loose stools continue. I only wish that my doctor had emphasized to watch for the gastric symptoms.
lorip
Re: Metformin, what dosage prolonged in how long before the damage sets in, kidney wise?
Lynn
Nebraska
I was on metformin 500 2x daily for a yr before I went into complete kidney failure.
Terry Graedon
Lynn, we are so sorry to learn of this. Metformin is not reported to cause kidney failure, but it certainly makes it worse. http://bja.oxfordjournals.org/content/91/6/909.full