Loading...
We have been writing about problems with generic metoprolol for more than a decade. This beta blocker is prescribed for patients with hypertension and heart problems such as angina pectoris, heart failure, rapid pulse and/or irregular heart rhythms. The drug was originally sold under the brand name Lopressor. A sustained-release formulation, Toprol XL, was introduced in the US by AstraZeneca in 1992. A lot of people take metoprolol. At last count the total was more than 15 million in the US. They expect this very old generic drug to work well, but does it?
The Secret of Sustained-Release Screwups:
What very few physicians, pharmacists or patients realize is that sustained-release formulations are unique. They are designed to gradually release the active pharmaceutical ingredient (API) gradually over time.
We suspect that many health professionals think that when a drug loses its patent the secret sauce is revealed to the generic drug companies so they can duplicate the brand name product exactly. Au contraire.
The way the brand name manufacturer makes its pills is a deep, dark secret. Coca-Cola does not reveal its formula to other soft drink makers and brand name pharmaceutical manufacturers do not share their secrets with generic drug companies. The generic manufacturers must reverse-engineer their copy cats. Sometimes they do pretty well. Other times, not so much.
We learned about this because of the antidepressant Wellbutrin XL 300. This brand name medicine releases its active ingredient, bupropion, gradually over many hours. Even after the patent was lost on bupropion, the brand name manufacturer retained the patent on the special membrane slow-release formulation technology.
The generic manufacturers had to come up with a different kind of formulation. The matrix some companies developed released the active ingredient differently and that led to all sorts of complications. You can read about the scandal we uncovered at this link.
Generic Metoprolol vs. Toprol XL Creates Confusion:
When AstraZeneca developed its brand of metoprolol succinate, it created a unique polymer microencapsulation process to deliver the active drug gradually. The XL in Toprol XL stands for extended release. We suspect that some generic drug manufacturers have had problems coming up with their own gradual release formulation.
In 2007, we started receiving messages from visitors to this website that generic metoprolol was not working as well as Toprol XL had. As more and more complaints poured in, we contacted the FDA about our concerns.
On October 21, 2007, we informed Gary Buehler (then director of the Office of Generic Drugs) and other FDA executives that there was a problem with the generic formulation of this and certain other important medications.
Gary Buehler’s response:
“We are investigating all aspects of this issue.”
FDA Inaction on Generic Metoprolol:
We heard nothing from the agency that year (or in following years) about its investigation into generic metoprolol. Nevertheless, over years we continued to receive complaints from patients who maintained that there were generic metoprolol formulations that were not working the same way the brand name Toprol XL did.
We received this question in the fall of 2022:
Q. I have taken metoprolol succinate ER for many years to control my heart rate. Back in 2007, I had lots of trouble when I was switched from brand name Toprol to the generic. So I went back to the brand name from AstraZeneca or an authorized generic. Fortunately, the VA used the AstraZeneca version in its mail-order pharmacy program. Now it has switched to a generic pill made in China.
This generic form of metoprolol does not work well at all. My heart rate shot up to over 100, so my doctor ordered brand name only and my heart rate is back to normal.
The price is astronomical, though, and it is always a fight with the pharmacy. They prefer to dispense the generic. What do you recommend?
A. Beta blocker heart drugs like metoprolol, atenolol and propranolol have a distinctive action on the heart. They all slow the pulse. The fact that your heart rate jumped to over 100 beats per minute strongly suggests that the generic metoprolol you took was not working.
You have a couple of options. There is a pharmacy in Lakeland, Florida, that carries the authorized generic metoprolol succinate formulation. That means it should be identical to brand name Toprol. You can find it online at www.EaglePharmacy.com. We have no connection with this pharmacy. A cardiologist we trust assured us that this authorized generic (AG) form of metoprolol succinate works the same way as the brand name Toprol XL.
Ooops! The Authorized Generic May No Longer Be Available:
That was then. This is now! As far as we can tell, this option may no longer be viable. Here is a recent message from a reader of our syndicated newspaper column:
Q. I’ve had trouble getting the authorized generic (AG) version of Toprol XL. I read that Melinta started distributing an AG but I’ve had no luck getting it.
I emailed Melinta and a pharmacist responded that they stopped selling the AG version of Toprol XL as of Dec. 31, 2023. He suggested purchasing the brand name if I wanted a high-quality product.
A. Toprol is the brand name for the heart and blood pressure medicine metoprolol. A cardiologist colleague has raised questions about the quality of some generic forms of this beta blocker.
When we checked GoodRx.com, we discovered that brand name Toprol XL is available for about a dollar a pill. That makes it reasonably affordable. Yes, the generic is cheaper, but if you want the brand name, the price hopefully won’t break the bank if you have a coupon from GoodRx. We have no financial relationship with GoodRx, just passing along information. It requires that you bypass your insurance, though.
Another option is to buy brand name Toprol XL from a legitimate Canadian online pharmacy. When we checked by using PharmacyChecker.com we found prices ranging from less than 50 cents per pill to over $1.30 per pill. The variable price depends upon where it is shipped from. Many legit online Canadian pharmacies have partnerships with worldwide pharmacies. Some pills come from Australia, New Zealand, the UK or Mauritius. The origins of the country can impact the price of the brand name product.
To learn more about authorized generic drugs and how to identify reputable Canadian pharmacies, you may wish to read our eGuide to Saving Money on Medicines. The online resource is available under the Health eGuides tab.
More Examples Of Generic Metoprolol Problems:
Roger described a blood pressure problem back on December 9, 2007:
“I had been taking Toprol XL for six years with no problems. When the generic (metoprolol succinate) came out, I was switched to that. All was well for a while but then my blood pressure shot way up. I started having dizziness & numbness on the left side of the face. I also had difficulty breathing and anxiety.
“The pharmacist told me that she has heard a ton of complaints about metoprolol succinate and that it is not the same as Toprol XL. She stated that Toprol XL is a time-release formula & metoprolol succinate is not.
“I had my cardiologist switch me back and I started feeling better right away. By the second day my BP was back to normal.”
Stephanie experienced heart rate complications:
“Generic metoprolol ER is not the same as Toprol XL. My pharmacy gave me generic metoprolol in December and within two weeks I started having irregular heartbeats.”
Nancy also developed arrhythmias on generic metoprolol:
“After taking Toprol XL with good results for three years to control cardiac arrhythmias, I was given a generic substitute three weeks ago when I switched pharmacies.
“After taking the daily dosage for five days, I began having more and more arrhythmias to the point of having to be admitted to the hospital. There were no other differences in my daily life.
“After discharge, I returned to the unused brand name drug (Toprol XL) and have had no further problems.”
Debbie describes a problem with her blood pressure that is quite compelling:
“I have been taking brand name Toprol XL for quite some time without any problems. Last week, I ran out and my doctor phoned in the refill for a generic prescription. I received metoprolol ER.
“I took it for 7 days. This is absolutely NOT the same. I have a blood pressure cuff that records my last 100 readings. During about the first 12 hours after taking it, my blood pressure was way too low. During about the last 12 hours, my blood pressure was much higher than it ever was. I am on my way now to pick up a new prescription for the brand name, at an additional cost to me, of course.”
Linda developed an alarming heart rate:
“I was recently taking Toprol XL for a heart rate problem called SVT and was doing fine. Our drug coverage changed and the mail order drug company sent me the generic metoprolol succinate ER tabs.
“About a week after starting the generic drug I was awakened at 5:00 am with a heart rate of 188. We went to emergency and they got it under control. This happened 3 times within a four week period and finally my husband and I told the doctor the only thing we could think of that had changed was the generic drug.
“She immediately wrote a new prescription for brand name Toprol XL. I never had another problem.
“As I understand it, the generic is immediate release and is in the system for about 6 hours and that the Toprol XL is 24 hour time release. I am 54 years old without a blood pressure problem, but someone elderly could have a real serious BP problem on this generic.”
What Happens When a Pharmacy Switches Manufacturers?
We received this message from a visitor to this website:
Q. I’ve been taking metoprolol for about ten years. For a long time, I took one particular generic and it worked fine. Then the pharmacy switched suppliers. After a few doses, my arrhythmia and rapid heartbeat started to recur.
Now the cardiologist’s office is trying to get my insurance to authorize brand name Toprol XL, so I can take something that will work. Why are we expected to use generics that are low quality? I Googled the maker of my current generic metoprolol. They have had numerous recalls.
We have continued to alert the FDA about serious problems with various generic metoprolol products. For people with hypertension, irregular heart rhythms or hypertrophic cardiomyopathy, having a medication that does not work as anticipated could turn into a life-threatening situation.
Adverse Reports Around Metoprolol
A report from Bloomberg News several years ago noted that the agency had received 3,425 adverse incident reports for the drug including “lack of effectiveness,” as well as “troublesome side effects.” In this Bloomberg report, the FDA made it clear that in initial tests, generic forms of metoprolol succinate dissolved properly. That seemed to suggest the FDA had tested various products and found they had all passed muster. The way a pill dissolves in a test solution provides some indication how well it will dissolve in a human body.
But that all changed on May 14, 2014. Without a lot of fanfare, the FDA noted that the Indian drug company Wockhardt had a problem with its metoprolol. That prompted the recall of 110,000 bottles of 50 mg metoprolol succinate.
Should FDA Revise its Criteria?
Perhaps even more worrisome was an acknowledgment by FDA spokesperson Sandy Walsh that the FDA was rethinking the criteria it has used for decades for approving generic drugs. We were gratified to learn that the agency was rethinking its procedures, but we worry that there could be hundreds of products on pharmacy shelves that may not be working the way physicians, pharmacists and patients expect. And we have seen nothing that indicates the agency has actually modified the generic drug approval process.
A GAO (Government Accountability Office) recommendation in February 2022 encouraged the FDA to make unannounced foreign inspections to really assess quality control. The GAO also recommended evaluating different types of translation services during foreign inspections. In addition, it urged FDA to recruit and train investigators specializing in foreign drug inspections. This all seems obvious to us, but apparently the FDA has been slow to implement these essential practices. It abandoned its efforts to make unannounced inspections.
BOTTOM LINE:
There was a famous phrase uttered aboard the Apollo 13 moon flight on April 14, 1970: “Okay, Houston, we’ve had a problem here.”
For 25 years, we were among the country’s most stalwart supporters of generic drugs. But for the last 20 years we have been telling the FDA that we have a problem with some generic drugs. We suspect that there are also issues with the FDA’s approval process.
We also suspect that there are serious problems with manufacturing quality, particularly in countries like India and China where the FDA does not have adequate personnel to carry out inspections. COVID-19 made everything worse!
If you would like to read more about the details of our investigation into the generic drug problem in America and the FDA’s inadequate oversight, we offer our eGuide to Saving Money on Medicines.
You will discover the details behind the Budeprion XL 300 debacle and learn what steps you can take to avoid generic drug disasters. Not only will you get details about acquiring authorized generics but you will find out how to save money on brand name drugs purchased from legitimate Canadian online pharmacies.
Please share your own generic drug experience (positive or negative) below. We are especially interested in metoprolol stories, but please let us know about any generic drug you have taken.
Bob Moyer
Here it is 26 Sep 2024, and I didn’t realize the brand name of Toprol XL was given to the company Melinta as the authorized manufacturer. It is NOT working well. I get jitters and arrhythmia in the afternoon now. How can they tell both the generic and the brand name? Who is checking the product lines to ensure some of the generic is simply stamped (A-B) and sold as Brand? And what is the difference in the products? Why would you even be allowed to sell the junky generic brand if it does not work as well? I’m contacting an attorney.
Patricia
When my doctor first ordered Toprol xl for me 20 yrs ago they automatically gave me Metoprolol. At the time I didn’t know the difference – but after 8 months of taking it I developed Bradycardia (40’s)- Swelling of my ankles and feet – terrible cramps in the calves of my legs. I asked the pharmacist which one of my medicines was causing all this and he said – Metoprolol – I called my doctor and she ordered Brand only Toprol xl, and all those symptoms went away. Metoprolol is a terrible drug: my dear friend came to visit us and his ankles were swollen over his shoes – I asked him what medicine he was on – Metoprolol. I told him to call his doctor. I pay a lot for my Toprol xl – but I don’t care – it is worth it.
Susanna
I also have had a bad experience with the generic version. I knew something was wrong after three days of the India-made version. I had to change pharmacies, and so far the generic version is working. FDA needs to pay more attention to these dangerous drugs.
Bruce
I was going through the period around 2006-7 when my Dr and Insurance would not continue prescribing Toprol XL and switched me to generics…I was sick for weeks and finally just started paying for Toprol XL out of pocket – even though I was unemployed and broke! Going back on the original Toprol XL brought me back from the misery I was experiencing.
Marty
Your article about generic forms of metoprolol deals almost exclusively with the long acting forms of the drug. It’s quite apparent that generic manufactures are experiencing problems with this long-acting formulation.
The most common strengths of immediate release metoprolol tablets are 25, 50, and 100mg and after using a number of different manufacturers have found them to be totally consistent in their intended actions when taken twice a day.
I originally started with the 100mg strength twice a day and was dropped down to the 50mg strength because it was working so well.
My out-of-pocket cost for a 90 day supply (180 tablets) is $10 and I take one tablet at 9AM and 9PM.
This is my regimen for over the past 12 years and it works very well for me. Not really hard to remember to take 2 pills a day 12 hours apart instead of one a day of a generic that causes more problems than the medicine solves.
Gayle
I too can’t take the generic metoprolol. I pay for the name brand Toprol XL out of pocket. I just don’t understand why insurance including medicare won’t pay for at least part of the name brand. When you are taking something that’s suppose to help your heart but instead is causing more heart issues, then something needs to be done!
Jan
When my husband was dying of pancreatic cancer and on Hospice, his oncologist raised his dose of oxycodone, and since the higher dose had a generic “equivalent”, Hospice automatically went to giving him that. The generic did NOTHING for him; he was in agony. He was told to take two of the pills he had been taking before the switch, and the doctor then ordered his meds at that dose, telling him to take two rather than one; that way, he was able to avoid the generic (not available at that dose) and had his pain relieved (to the degree that was possible).
Lew
So, apprantly the issues with generic metoprolol ER continue, sadly, for way too many.
My PCP switched me from 25mg 2x a day immediate release to 50mg ER Metoprolol once a day. I was having high blood pressure readings in the morning. Was told to take ER tab at bedtime.The script was filled by OPTUMRX mail order, the generic ER Metoprolol was manufactured by INGENUS.
Everything was fine for about 2 weeks with the ER version then about 10:30 one morning I had a rapid heart rate (110-120) and high blood pressure 160/79. It gradually dissipated during the day. By the time I spoke with my PA by 15:00, things were normal.
The next morning, 04:30 it happened: rapid rate, forceful and some PVC-type arrhythmias. Decided to go to Emergency, thought maybe they could capture event on a ECG.
ECG, was negative by then, but heart rate was around 105 and BP 180/85. Was there way too long; they had several other emergencies, but when I left 6 hours later, BP 140/79 and heart rate 100.
After getting home I decided to go back to the immediate release version of metoprolol.
No problems for next three day. So, Thought I’d return to ER version. Maybe just a fluke. I was wrong. The rapid heart rate and arrhythmias symptoms returned early next morning.I took 12.5 mg immediate release, which settled it down in about 45 minutes.
Seeing that my doc appt was about 16 days off, I decided to go back to taking the immediate rls version.
I did so for 12 days, no problems during that time, things were great.
However, just to prove to myself one more time, I changed to the ER version. Two days later the symptoms were back. Fortunately, I had plenty of the old immediate release pills left. I returned to the immediate realease tabs and will see PA in 3 days. Should be an interesting converstation.
I am not a big believer is coincidences, especially three times.
But, As far as I’m concerned it is the extended-release metoprolol that is the cause of my issues.
Interestingly, five years ago prior to having open heart surgery I was taking generic metoprolol ER, with no issues. Sadly I have no idea of the mfg.
The current ER generic that is giving me issues is INGENUS.
I wonder if there may be too many manufactures now and too little oversight by the FDA.
Cindy
Does anyone have issues with Dr. Reddy’s generic metoprolol 25 mg ER and gum irritation and burning and throat sores? 4 hours after I take my pill, I have gum and throat irritation. I never had these issues with other generics or the name brand drug. I have been taking the medication for a few years but never from Dr. Reddy’s until last few months and then the problems started.
Art
I tecently had a terrible expericience with metoprolol xl 100 mg by camber pharma. Fast irregular heartbeats for no reason that would take an hour or more to return to normal. My pharmacy has changed manufacturers a few times and now I’m using Dr Reddy’s which works great. It’s crazy that different generics work and others are ineffective and dangerous
BB
I was prescribed Metoprolol for the first time last year. I did not experience negative symptoms or adverse side effects. Metoprolol slowed my heart rate, which, with my history was a good thing. However, the MD & Pharmacists did not agree on the minimum heart rate effect. The dosage I am taking has kept my HR mostly in the 60s bpm. Not below 60 & some occasional spikes into the 70s.
The pharmacists were patient & diligent for finding manufacturers of this med – that did not have lactose as an “inactive ingredient.” For decades I have had to ask for the product insert on every new med to check for lactose.
Another good thing about getting these meds from from the my pharmacy is that the manufacturer name is coded on the label with my prescription. One dosage bottle comes from Dr Reddy’s. The other dosage label is marked TEVA. Having the manufacturer name on the bottle helps me track whether I’m receiving a med from a different manufacturer.
Amy
I have noticed sometimes the 90-day metoprolol generic prescription I get from my pharmacy works well, and other times it doesn’t. I have been happy with the formulation recently, but just got a refill and am nervous about the effects. It usually takes me a while to figure it out. I get palpitations, racing heart, etc.
My daughter was on Concerta generic and noticed issues when manufacturer changed. She has moved to the UK and noticed lots of problems. So much so she has stopped the meds (sleeping issues, jitters, anxiety).
Ilene
It was suggested that one could purchase necessary pharmaceuticals from legitimate Canadian online pharmacies. But if you are on Medicare, don’t you have to stick to your designated pharmacy?
Larry
I’m surprised no one has mentioned the other form of metoprolol, which is NOT extended-release. I take metoprolol TARTRATE, 25mg a day. I actually cut the tablets in two and take the resulting 12.5mg every 12 hours. Metoprolol tartrate wears off gradually over an 8 to 12 hour period. I’ve taken it for more than 15 years, and it was originally prescribed to “prevent a heart attack.” I had a triple-bypass coronary artery surgery in 2007, but the main graft (mammary artery) failed after just a few weeks, which is quite a rare occurrence. I’ve survived anyway, by keeping my cholesterol under control (with atorvastatin and diet).
A couple of times over the last 15 years, it’s been suggested that I should take metoprolol succinate instead. I have tried that, and I really don’t like it — primarily because of the way it makes me feel at night. I get really bizarre dreams and don’t sleep well. I much prefer using the metoprolol tartrate. I was originally on a higher dosage — like 100mg per day (50mg 2X a day). But over the years the dosage was reduced, and now I get along just fine on 12.5mg 2X a day.
Wendy
Another generic that is having problems is Adderall XR. Many people on the ADHD social media groups are reporting that the generics are not working.
Bruce
I too was prescribed Toporol XL for high blood pressure over a decade ago. My insurance began switching me to a generic Metoporol (sp?). I started having many issues…palpitations, arrhythmia, general dizziness, and more. I was a regular reader of People’s Pharmacy back then, as I still am now, and read some issues being reported with Metoporal…I mentioned this to my Doctor and it was obvious he thought I was being a bit stupid believing there might be something in it. It got so bad that I finally told the pharmacy I would not accept the generic and would pay out-of-pocket for Toporal XL. I almost immediately felt better. I could not continue paying full price indefinitely so was switched to one BP med to another…Lisinopril was a Coughing Hell – don’t want to revisit that for sure! Finally put me on Amlodipine…I’m sure its a generic…getting it from the VA. So far things have been fairly decent for a change.
Sheryl
I pay a lot for good insurance though my employer for United Healthcare Choice Plus. Fast forward. I have long-haulers (COVID) and suddenly have tachycardia constantly & constant PVCS (heart palpitations) that I feel constantly. I do not have any underlying heart issues. So after many tests, and once they confirmed I had it, said it must be due to long-haulers COVID.
I was put on Brand Toprol XL. I am sensitive to a lot of medications, and have problems with the fillers & dyes. I have a lot of medication allergies, so I’d rather take nothing if I can. Who can go around feeling racing heart at complete rest & palpitations like you’re being kicked in the chest, pausing the heart and then continuing every so many seconds???
I do not have high blood pressure. Actually, it has always been on the low side, so that’s a concern too. I hesitantly tried the Brand Toprol XL and gave it a chance, and it worked to help calm things.
Fast forward, and suddenly the pharmacy switches me to generic after I’ve been taking brand Toprol xl because my insurance suddenly removed it from the approved list. I tried the generic metoprolol succinate E-R, and it does not work at all. All the symptoms came back, and actually feel worse and more pronounced. I called the pharmacy and we tried a different generic, and the same thing. Neither of them work at all, so how are they a generic of a BRAND?
My cardiologist tried to get authorization through the insurance for the Brand Toprol XL, but they refused. My cardiologist sent me to the electrophysiologist because she doesn’t know what she can do. The dose can’t be raised due to my low blood pressure. I’m allergic to a lot so that’s an issue too. She said there was one other med that might work for me, but it has to come from the electrophysiologist. So I complied. I was put on Diltiazem CD, and my face blew up. Stopped immediately. Major fail.
Why am I being treated worse than a dog? Why am I being treated like a guinea pig? I went back, and the electrophysiologist says they’re at a loss because I can’t be put on a lot of things, and they don’t know what to do either, and their hands are tied. They came up with a last ditch effort, that they didn’t even like: 1) raise the dose of the med to see if it works, but I have low BP so it most likely will bottom-out my bp causing issues or 2) go old school & try Pindolol if can find it at a pharmacy.
I got the Pindolol, and the pharmacist told me, as it states on the included information that I cannot take it due to asthma & being on asthma medication. Now I’m out more money, and have to throw it in the garbage. I let the Dr. know.
Strike 2, I pay an arm and a leg for insurance, and since they aren’t covering brand Toprol xl and calling it an exemption, even with a discount card, it’s a 130 bucks for single dose, which is too much out-of-pocket. So double that for 2 pills. That’s outrageous! Who can do that when you pay for insurance. I can’t.
So now what? I need a refill on brand Toprol xl at the increased dose, and I can’t afford it. My cardiologist tried again with prior authorization, considering that other drugs have failed, and I have known allergies. They still refused “just because.” So then my cardiologist wrote a letter of exemption (I’m not sure what it’s called) that goes a step further, and should be approved. They said it could take up to a month to hear back about it.
Finally, I heard back, and the nurse is beside herself saying she has never encountered anything like this before. I was denied again.
What the hell am I to do? Obviously they want me to drop dead. I’ve always had issue with an insurance company dictating what you can and can’t take.
This is my life on the the line. I’m disgusted, and my cardiologist is disgusted.
Other than drop dead, what am i to do?
John
Coming across this info as I am wearing the Holter for the first time in a long time. My local CVS Pharmacy switched brands recently after 8 years of using the same one Metoprolol Succ ER 25 mg oval A B on the front from Lannett, this “new” “same” med from Ingenus oval N 25 took about 2 hours to start having palpitations again, every few minutes, and my arrhythmias to start bothering me again which had been controlled with Flecainide Acetate 100 mg 2x day. It’s been 1 week, and each day I feel worst. I’ve been looking online trying to find a pharmacy that has the brand I used to take – Hoping I find one soon.
Brenda
I started taking Toprol XL brand name in 2000 for heart palpitations, and it was a complete success. I was then switched to the generic, metoprolol, and within 2-3 days I started having vomiting, rash, severe headache and my PVC’s returned much more frequently and lasted longer.
My physician switched me back to the brand name, and things immediately settled down. Years later, I found a patient assurance company in Florida, Eagle Pharmacy, who offered the brand name drug for 50.00 for 3 months (I take 50mg BID). Wonderful!! But soon they went out of business, and since that time, four years ago, I have been paying 155.00 a month for my medicine. Interesting note, Eagle pharmacy is now offering the generic metoprolol for patient assistance, NOT the brand name.
I am on Medicare and won a case where they must help pay for some of the cost of this drug due to my severe allergies but it’s still very expensive each month. I have been unable to find another patient assistance company for the brand name Toprol XL. Even Canada supplies the generic made in India. No thanks.
This is so frustrating that I am among thousands of people who have problems paying for a medicine but have no financial help/patient assistance available. Yet drug companies record billions in profits in year.It’s time to turn the tables and help the people who rely on these meds to stay alive. It’s sad that someone who makes 800/month must pay 155.00 of that for one medication. There is something wrong with the system in this country.
Mike
Brenda, I had the same problem. They told me that Lannett no longer makes it. Dr. Reddy’s makes me have PVCS. I’m scared. Did you ever find something to help you?
Be
Sorry this is about a generic other than metropolol, but it’s probably necesssary to make known the issues with any generic, especially since many are mamufactured in India and China.
Teva Clonazepam has been the go to generic of Klonopin not just for myself, but many other patients out there have issues with generic other than Teva. If I ordered Clonazepam without asking specifically for the Teva generic, often the pharmacist would dispense a different generic, either by the Par generic, which commonly caused anxiety and other psychological issues.
For myself, within a few days of starting on Par clonazepam, I would be in a mental state even worse than not have the brand, as if I had nothing at all. I didn’t realize how widespread this was until I started researching and found that a lot of patients, male and female, had issues with generic clonazepam and that it was the Teva generic clonazepam that was the one that gave anyone relief, as it did for me.
And Now, TEVA has Stopped making generic clonazepam for the second time. They restarted after ceasing around 2018 or 2019, and restarted early 2020 but all of a sudden, they stopped again early summer 2021. I searched all over for it and finally realized it’s not available anymore.
Please, Teva, please go back to making generic clonazepam. I am personally even willing to pay a higher price for it.
LI
Fortunately, the generic brand of metoprolol succinate ER that I have been taking for a little over 4 years for hypertension seems to be working O. K. It has been the same generic manufacturer throughout.
Teresa
I have taken TOPROL XL for 9 years. I have tried different generics and they never worked. This year, I contacted ValisureRx (rebranded to Medley Certified) and have finally found a generic I can take. OMG – the money I am saving. I was spending $51 a month and now am paying $31 for a 3 month supply and it is working. Paying out of pocket. I would highly recommend contacting Medley @https://certified.medly.com/signin.
Jill
That article is fascinating. I knew I was taking a generic and when I actually looked at the label: “kapspargo sprinkle”. The 50 mg dose was prescribed when I weighed 235 (female). I now weigh 170 and think I should be reevaluated. I still have bouts of afib . Made a serious mistake though the other day. Decided to take metoprolol at night instead of in the morning. Had two nights of incredible nightmares and looked up side effects. Yep. Nightmares from metoprolol. Will get in touch with my dr. Thank you for this article!!
Lida
How can you know for certain that you are being supplied with the actual brand toprol xl and not the generic?
Tom
When I saw the Indian vendor, it immediately answered the concern about faulty efficacy. I refuse to use drugs manufactured in India and my pharmacy graciously stocks the alternatives for me. It took some time and convincing, but they were very gracious about this.
So my point here is ASK your pharmacy to fill your meds from an alternate vendor and if they say they can’t then change your pharmacy. The reimbursement back to the pharmacy from insurance companies is the same.
Gayle
I have had atrial fibrillation for years and can only take the name brand Toprol XL which I pay for out of pocket since my insurance won’t pay for the name brand. Tried the generic, but made me heart act up so, to me it’s not worth the risk! Just hope I can continue to afford paying for the name brand myself!
Joe Graedon
Gayle,
You might want to explore a reputable Canadian pharmacy. The average retail price in the US for a month’s supply of 50 mg Toprol XL is about $60. The brand name Toprol XL via a Canadian online pharmacy should be about one third that price…or less.
Luke
I remember mom used to be on Toprol XL until there was a shortage so the shorter acting metoprolol tartrate was substituted. Taking it twice daily (shorter acting) worked so well we kept her on the tartrate
Jay
I was switched to the generic metoprolol by my pharmacy. I began to have short term memory problems. My arrhythmia was off and on, but more severe when it happened. My heart seemed to be going very fast, even when I was resting. I lost 12 lbs in one year. Then my hair started to fall out and I was becoming a zombie with either no thoughts, or sad thoughts. I switched pharmacy’s and requested the brand name instead of the generic. This morning it feels like a veil has been lifted off my brain. I am happy again, and my heart has a regular slow beat. Toperol XL is working
L.H.
US
Because of A-fib, I’ve taken generic metoprolol succinate 25 mg. twice a day for quite a while, but sometime ago I noticed that the shape of the pill had changed (I have been getting them by mail through my insurance). The shape went from round to oval. The manufacturer of the oval one is Dr. Reddy, an Indian company. I’m not sure who produced the other one I took, and I’m not sure when exactly I started taking the oval one.
Since spring, my A-fib has become chronic. I just figured it was getting worse, which I’ve read is the natural progression. In addition to the irregularity, my rate was also out of control, often being well over 100 even when I was just sitting and doing nothing.
My new cardiologist doubled my dosage to 50 mg. twice a day, and nothing changed. My heart was still out of rhythm nearly all the time and my rate was out of control. Then a relative called to ask if I was still taking that drug. She takes it for hypertension and had switched pharmacies. The generic’s manufacturer was different for the new pharmacy, and after she started taking that one, her bp got out of control. She got her doctor to write her a prescription for the brand name version, Toprol XL. I called my doc and got the same.
I started taking the brand name drug on the Tuesday before Thanksgiving, and my heart rate started dropping within the first day or so. I was still taking 50 mg. twice a day. By Friday, my heart rate seldom got out of the fifties, even when I was active, so I reduced it to 50 mg. in the morning and 25 in the evening. Today is Sunday. I did some light exercise this morning, and my rate did make it into the low sixties, but is still in the fifties most of the time, so today I’m reducing the dosage back to 25 mg. twice a day. Even with the very low rate, I feel fine.
Besides the good news that my heart rate is getting under control is that my heart rhythm is now normal most of the time. I occasionally notice a skipped beat, but for the most part, it has stabilized. Yes, I had to pay cash for the brand name because my insurance won’t cover it, but I consider it money well spent.
A.M.
IL
I’ve been taking atenolol for 10 years working perfectly to keep me BP under control. Last week I was informed that there was a shortage in the production for atenolol. They were switching all patients to metoprolol succinate ER. I started Tuesday and the very next day I felt palpitations. I knew something was off. One week later, my head felt like it was exploting and started having chest pain. I check my BP and it was the highest ever! I ended up on the hospital, they did a stress test (passed), and my BP went down to normal when they switched the medication.
Kim
Portland, OR
Please, what did they switch you to (from the metoprolol)? I’m in the exact same situation; Atenolol = perfect, Metoprolol = palpitations, racing heartbeats, and vastly elevated BP. IF you’ve found something that did work for you, please advise!
Diane
Eugene, Oregon
I have taken metoprolol succinate for SVT (irregular hb/tacchycardia) about five years, generic version with no trouble from Hirons Pharmacy. Then Feb 8 got the prescription renewed. I thought nothing of it until about the second day I had some palpitations and irregular heartbeats. By the end of the week I noticed I was feeling similar to when before I stated meds. The next two days I had two episodes of tacchycardia. The last one was a good five minutes.
That’s when I called the pharmacy to ask if they ever had prescriptions that were accidentally the wrong medicine- since I sure felt my heart misbehaving as though I was off the med. They told me that never happens but they did switch their source for this generic recently.
It finally dawned on me to ask my NP to re- prescribe me the brand name, Toprol XL which made an immediate difference. Had to pay cash, 17x more expensive. The first night the palpitations stopped and regular beats are happening again. Bad generic company! This is day two and my BP is still high. I have an appointment with my NP next week.
Jordan
Boca Raton, Florida
I was diagnosed with SVT last year, after being hospitalized twice in one week. The doctor put me on metoprolol. It seemed to work ok for a little while (with some side effects), then I started having palpitations again, so my doctor switched me to brand name Toprol. Wow! What a difference! It costs a lot more, but it works so much better. The generic is definitely NOT the same as the brand name.
Mercedes
Coral gables
My hair is falling out with metoprolol 100 mg. Will toprol close be better?
Tricia
Powhatan VA
I’ve been taking Metiprollol for about two months for high BP.
It got my BP to normal. Recently got a refill and it does not control the BP at all anymore. I’ve gone on internet and found others have had this interesting issue. I am trying to find the brand in pharmacy at this time to see if this will make difference. We should not have this problem in our United States.
Stanley
TX
I have had hbp for twenty years or so controlled, but lately it has gone much higher as much 206/94, which was a scare, i was out of one prescription which was Metoprolol and ordered it again and my blood pressure is now at 153/84 which is lower but really not low enough. This Metoprolol is made by Astrazeneca. Hope it is of better quality.
Donna
my experience too & have read recently that it makes BP surge when its not working correctly & that is OFTEN!!!
Bela
USA
Doctors seem scared to admit that hair loss can happen from the med(s) they prescribe. They plead ignorance on the subject and ascribe the side-effect to “genetics” or “nerves” or “stress” or “hormones” or “aging” –anything but their precious drug!
J
FL
I took generic metoprolol succinate ER (extended release) for the past 15 years from my family practitioner for benign tachycardia (just fast heart rate with no known cause) and I was just recently sent by my mail order pharmacy the ones from Watson which I had never had before. They are very thick pills, very different from all the other generics before.
Anyways, I started having severe arrhythmias that caused dizziness, lightheadedness, and general nausea. I felt like I was going to die. It was scary. This would come and go and went on for 30 days. I kept thinking it would go away since I’m extremely healthy other than the fast heart rate.
It became hard to fall asleep because the arrhythmias would start up badly after laying down to sleep at night and would immediately wake me up once I finally got to sleep. So I began looking into seeing a cardiologist to have a holter or event monitor. But then I thought maybe the pharmacy sent me the wrong pills so I searched the tablet imprint online and found it was correct.
But the search led me to this website, and I realized these arrhythmias could very well be caused by this new generic I began a month ago. So, I count the pills, and sure enough, I took right about a month’s worth. I still have a few of the old ones (not from Watson) that I had added to this new bottle so I am only taking the old ones now as of today and in a few days I will know if these Watson pills are the culprit.
If so, I will report my side effects to the FDA. And I will have to call my doctor for a new order and pay full price from a local pharmacy. (Yet another reason I can’t stand mail order) maybe it’s the hypromellose??? I don’t know about that. I’ll have to research that for sure
sheila
new york
I totally agree about metropol, as I have been on Toprol XL for years. For the past year and a half my blood pressure remains at 120/80 with no problems. Now my pharmacist has switch me over to metropol and my BP has risen to 140/90 and higher in the pass three months (2017). My doctor has tried to convince me they are both the same medicines, which I have totally disagreed with him and the pharmacist. I’m so glad to have come across this article. I do NOT want to take generics for anything pertaining to my heart. I also take coumadin which I need an update on that medication. Thank you!!!
sheila
new york
I totally agree about metropol, as I have been on Toprol xl for years. For the past year ans a half my blood pressure remains at 80/120 with no problems. Now my pharmacist has switch me over to metropol and my BP has risen to 140/90 and higher in the pass three months (2017).
My doctor has tried to convince me they are both the same medicine. Which I have totally disagreed with him and the pharmacist. Im so glad to have come across this article. I do NOT want to take generics for anything pertaining to my heart. I also take coumadin which I need and update on that medication.
sheila
I would like to see an article on taking metopol XL when on coumadin therapy. I presently take coumadin 4mgs every day and the tropol 50 mgs. morning and night. I need to know if there is any interaction with these medications. Please reply
Terry Graedon
No particular interaction popped up in a check on epocrates.com
Donna
they are NOT the same!!
Gene Hoilman
Virginia
On March 24, 2017 the Doctors opened up one partial blockage and put a stent in the completly blocked vessel. Afterward they gave me a prescription for Metoprol ER succ. After three doses I began having extreme fatigue, headache, and nightmares at night. Thank GOD my drug company sent me Toprol XI and the side effects are almost gone. I still have a little tireness but nothing like before. I was taking toprol at night but bad dreams started back, so now I take Plavix and toprol at the same with very after effects. The generic med Metoprol Er is not good. Hope this helps someone. Gene
Rosey
Ohio
I have been taking the Brand name Toprol XL for years and had to switch insurances. My past insurance sent me the brand name and only charged me the generic price. They said there was a problem with supply but they continued to send it for years at that price.
Since changing insurances this year I started receiving the generic. I hadn’t used them yet since I still had some of the Brand Toprol left. I accidentally grabbed the wrong bottle and filled up my 2 weekly containers with the generic. So for 2 weeks I was taking them and felt awful. No energy and the bones in my arms ached and felt like I couldn’t function until late afternoon when I started feeling better. It didn’t dawn on me that it was from those generic pills until when I wanted to start filling up my containers again. I saw where there was one left in my pill container and saw that it was generic. So I counted the pills in the generic bottle and exactly 14 pills were gone so then I knew I had taken them.
Next day I started the brand one and and feel so much better. Don’t have those symptoms anymore. I am going to call the doctor for a new prescription for the Brand but it is very expensive for me.
Charlotta
Houston, Tx.
For over a month now I have been feeling (I know this going to sound crazy) what feels like a very faint electrical charge/current in my heart. After much thought, I began to think maybe is was valve regurgitation. I don’t have medical insurance so getting an echocardiogram is not an option, they are too costly. I have been on Metoprolol for over 3 years now and wonder if the ingredients in this medication could cause a valve problem. If anyone knows if would greatly appreciate your input.
Julie
Illinois
I have just started taking Dr. Reddy’s Metoprolol Succinate ER Tab 50 MG. After taking for only four days, I have a concern. Weight gain. While this may not ring as an issue to most, having a weight problem has me hyper-vigilant. Portion sizes are minimized with food quality highly stressed. Weight loss has been between 2-3 pounds a week. Now, I am gaining 2-3 pounds a day!
I am not an obsessive stick person. Along with my CHF came a significant weight gain that I have successfully been chipping away.
Now, this generic pill has me gaining without any other cause and effect. Is this usual? Is there an ingredient that would cause this?
I have recently moved and started with all new physicians. I don’t want to blow my credibility as a sane person…. I have a real concern. Any suggestions, greatly appreciate.
Fred
Pace
I was given name brand meroprolol er 50 mg this time and have been on generic for 6 years.I’v always noticed this thin name brand metoprolol pills caused me to be very irritated and angry feeling when I took them but I also have some heart irregularity on my normal generic so maybe I will try this name brand and see what happens.I do know their is a major difference in namebrand VS generic drugs but the pharmacy will NEVER ever admit that to you.I also think they should have told me I was getting a different brand also.
joann
long island ny
Heart attack 2012, prescribed Metoprolol, taken without incident 4 yrs. Until this week when I landed in hospital with chest pain, pounding headache, dizziness & blurred vision. Tests all fine. Still had headache & spiking blood pressure, more test scheduled. Upon review the only thing different was a new bottle of metoprolol from PAR via CVS. Reverted to a leftover older bottle of pills and symptoms immediately resolve. Medical personnel quick to dismiss? I am reporting this to CVS, FDA, hospital & insurance.
Ginnie
Maryland
I’ve been taking Metoprolol ER for 6 years (with NO problems), since my sudden cardiac arrest. Since my last refill about a month ago my average heart rate has steadily increased. It got so bad that I finally went to my cardiologist yesterday and he said that there had been problems in the past with generic manufacturers. Sure enough, I went home and looked up the “new” manufacturer – Dr. Reddy’s, based in India. There was a recall on their Metoprolol in 2014, and they currently have 3 FDA sanctions against them. WHY are we distributing life and death medications made by a company that repeatedly receives sanctions? (And by the way… Dr. Reddy’s? Really? Why not just call yourselves “Bob’s Drugs”!) I was switched to PAR today. We’ll see how that goes, but if it’s not better I’m going to brand.
SK
North Carolina
For some reason my pulse got out of control [never had been] and my BP was also very high. I saw your article in April or May of 2016 and shared it with my physician. I checked and my Metoprolol was from India. My physician changed me to Toprol XL and the pulse came back to normal and my BP has dropped. I am very grateful for the information as posted by The People’s Pharmacy. I am also hoping the hair loss will stop but so grateful for the other. Thank you so much.
CHARLES
BAYSIDE NY. 11361
After taking PRINIVIL for about 25 years my nephrologist switched me to METOPROLOL succinate ER 25 mg.twice a day. It worked until my last refill at my pharmacy was manufactured by PAR PHARMA (my original pill was round with a score this one is oblong with markings A & B;i must say that my blood pressure has risen 10 %?? my cardiologist shrugged it off but I am convinced that this pill is not doing its job;am I putting myself in jeopardy???
Dani
I just looked at my bottle it says:
METOPROLOL ER SUCC 25 MG.
PHARMACEUTICAL: PAR
Is this the Pharmaceutical that every one has had an issue with?
Any issues with TOPROL XL and the Pharmaceuticals?
Dani
Midwest
Iam a 54 yr. old female, was put on Metoprolol ER Succ 25mg. for Severe Migraine Prevention by my Cardiologist. Iam healthy, other than migraines, & a mild heart murmur. My cardiologist said I can’t continue to keep taking Relpax, & Imitrex 3-5 x’s a week, so he gave me Metoprolol ER Succ 25mg..
As a preventative for severe migraines. Well all was great in the beginning, 5 weeks ago. Headaches were less often. But now I’m having adverse effects such as: palpitations, very nervous, weak feeling, burning pain in back, & top of head, blood pressure goes really low 110/70, pulse 45, then at night might be 150/86, pulse 64, before my next dose.
I looked this medicine up & found out that there are others with the same side effects. I called my doctor today & asked to be switched to the brand name TOPROL XL..we shall see! I can’t continue & refuse to feel this way. It’s awful for me. Good Luck! :)
Carolyn
Cleveland, Tenn.
I had been taking toprol XL for years and had very few problems over those years with my irregular heartbeat. Then I was switched to a generic (metoprolol) .then I started having alot of problems with my irregular heartbeat. I made them give me the name brand back.I just started taking the name brand but it is not the same name brand pill I was taking before. The first name brand pill I was taking worked wonderfully but this name brand pill looks just like the generic one I was taking, in fact practically identical and so far it’s not working. I’ve been taking it for 3 or_4 days. It concerns me that it may not be a name brand. I just know that the original name brand pill worked so well and this one is different and it doesn’t seem to be working and that is the only change I’ve had . I can’t see anything that could be causing the problem. I feel that the problems with medications should be looked into alot more carefully. We are depending on the pharmacutical companies to do their jobs correctly. But obviously they seem to be filling to do so. My prayers are with everyone having these problems.
Jessica
Charlotte, NC
I have been taking the metoprolol succinate 50 mg for a cardiac arrythmia, PVCs. Before I left for my vacation, I had the 6 week follow up with my cardiologist to see how things were going. All was going well, medication was working and I felt much better. When I returned from my vacation, I received my new prescription bottle in the mail ( I had to switch pharmacies due to a new health plan) and after taking the new prescription, symptoms returned after 6 weeks of feeling great. Nothing else changed. I called the pharmacy about the manufacturer. The oblong shape from Par-pharm was very effective for me but the round pill marked M2 did not work for me at all, with symptoms of palpitations and increased anxiety (due to palpitations). The point is, pay attention to the manufacturer. …there are differences! I have to unfortunately pay out of pocket for the better manufacturer.
Helen
Memphis, Tn
For years I took Toprol XL for irregular heartbeat, with little or no problems. At one of my visits to my cardiologist, my prescription was changed to Metoprolol ER 25mg. I noticed that the heart palpitations began to get worst, so I was prescribed a monitor for one month to record any irregular events. After none was found, the cardiologist increased my dosage to 50mg. I was very uncomfortable with this decision, noticing by blood pressure dropping very low, along with an increase in headaches since taking the Metoprolol ER. I was delighted to accidentally run across this site, because I have been thoroughly enlighten. I will have this discussion with my doctor on the next visit.
elaine
boston
Also had hair loss on metoprolol I am now on lower dose. But have been suffering from anxiety on it cardiologist doesn’t think it’s from metoprolol but didn’t have it before like this
Joan
Florida
I began to have problems with Metoprolol and was becoming a zombie, along with irregular heartbeats, trips to the hospital, etc. So, I began reading on my computer. I saw that this generic drug was having problems, and they all sounded like MY problems. I inquired of my insurance company and was told that I would have to pay for my TOPROL XL – and so I did! What a difference! Now and then my blood pressure rocks and rolls, but much less frequent, and is usually due to my eating habits, etc. No way will I be convinced to try Metoprolol again. Also, if it is so evident that these generics can be dangerous – why then do our insurance companies refuse to pay for the real thing???????????
Laureliete
United States
Toprol Xl does not have the inactive ingredient hypromellose. This flowery sweet name was changed in the last few years from hydroxypropylmethylcellulose. And with very little close to no fanfare at all. Very deceptive. It IS in some of the metoprolol generics. Watson brand for example is one. I can’t take hypromellose. Twice it was in a drug I took daily. The first time I ended up in a coma with heart failure, liver failure and kidney failure. I had no risk factors at all. I’m lucky to be alive. The second time worsened the heart failure from the first time. Two different drugs both with hypromellose in common. No other daily drugs I took had that in it. It could be a coincidence but I’m not willing to risk my life. Last year went on one more drug with that same inactive ingredient and saw my liver enzymes begin to soar within the first two weeks. Went off that drug immediately. It is not the same as cellulose compounds don’t know why Watson would substitute it so unnecessarily. It must be cheap because it is showing up in everything from aspirin to face wash. By the way it is also used in industrial adhesivives. Go figure!
Donna
Indiana
I am on Metoprolol Succ ER and have been having PVC’s, I also have other heart issues but these PVC’s are driving me crazy, and after reading all these stories I’m beginning to think it is this generic medication. I’m going to call my Dr. and request Toprol XL, and see what happens I to will have to pay for the name brand but it will be worth it. Has there been any law suit against this manufacturer?
paul
I am 60 years old and was switched from a beta blocker to a channel blocked ( metoprolol) 7 years ago. It was actually my ex wife driving by that started the paul is losing his hair rumor in an excited way.
I ignored her gossip until a couple years ago when I realized I was shedding hair faster than my black lab.
It was everywhere… in my hat, intertwined in my eyebrows, (also thinning disproportionatly), stuck In my glasses, on my robe, on my shoulders in the vacuum even.
I am not a vain man but when this became more than annoying I noticed the hair falling out was really really thin and enimic looking.
I did some research and found one of the side effects of metoprolol was hair loss. But it was so far down the list ait was in the very rare catagory.
I do not believe them.
As of last week I stopped taking metoprolol 200 mg and also amlodepine cold turkey.
even though my doctor had assured me my pulse would skyrocket in 48 hours without it, my pulse and blood pressure have actually improved. 138/78 pulse of 98.
I don’t care if I drop dead today, as long as I don’t lose any more hair!!
signed… waiting for hair
The People's Pharmacy
We do not advocate stopping blood pressure medication suddenly, and urge those on blood pressure pills to get their doctors’ guidance for getting off.
ditanya
baton Rouge la
I’ve been taking this medicine since I was 21 and now that I have read the side effects and what people was going through now I know that it wasn’t just me. I’ve been having dizzy spells been feeling light headed my anxiety is very up and I’ve been trying to switch to the brand name but my insurance don’t cover it covers the generic. so now I also have a heart veil problem also so I have eyes anyone that is taking this medicine talk to the doctor for the brand name cuz I’m 30 dealing with a heart veil problem and also with anxiety problem
Lee
United States
There is some misinformation here. Metoprolol Succinate is NOT the same as Toprol XL. It IS the same as Toprol. Metoprolol Succinate ER is the sub for Toprol XL. ER and XL mean Extended Release. If it does NOT have the ER on the name it is not extended release and will not perform the same.
I believe most of the people having problems switched from extended release (XL) to non-extended release unknowingly, which could cause adverse side effects.
elaine
Also getting anxiety
carmanita t.
tacoma,wa.
I just got this E-mail forwarded to me from a friend, I had the same issues too! I have been on and paid for the real Toprol xl too and I am so relieved to know I am not crazy! I can tell when its real and when its generic!
Kel
USA
So glad I read this article! I have been taking Metoprolol for several years for Hypertension. I was given the Wockhardt brand at a local drugstore and did not think much of it at first. The next day, I was covered in hives and itching all over. I could not attribute it to anything else but that. I returned it to the pharmacy and told them I wanted the previous kind ( which was Mylan ) instead. I never had anymore problems after that! I will never use anything Wockhardt makes again!
Heather J.
North Carolina
I have been taking generic metoprolol succinate ER (Par brand) for about 2 years without problems. Earlier this month I had my prescription refilled with a notice that my pharmacy had filled my script with a different brand. I have cardiomyopathy (reason for beta blocker) as well as thyroid disease & celiac disease. I knew immediately I had been glutened. The medication also is not sustained release that I can see. My normal 75 beats per minute heart rate has woken me up twice this week in the 130-140s range.
J.W.
I’ve been on Metoprolol Succ 50mg for approximately 8 years. Throughout that time I’ve experienced contiuous hair shedding. According to my doc, there is only a 1% chance it’s the Metoprolol. Wondering if anyone else is experiencing the same. The medication has been helpful in other ways.
Sha D.
Was twice in hospital & had to have stress tests, due to new time release pain meds. Now I wonder what I was given.
Regards
Carole N
Went to pick up my Metoprolol Succ 25mg – today and a notice said the pills may appear different but the content was the same. Since I have severe reactions to some meds, I questioned the change as I wanted to secure the same thing I have taken for 2 years. I checked with other pharmacies and found they have none of the metoprolol succ from Wockhardt. The pharmacist said they now only deal with Wilson as they are in the USA. I am checking with my regular druggist to see where they get the new generic, and I think I will check in the future for all meds and where they come from.
I am on Medicare and Blue Cross and they sometimes decide on their own what we should take, but with my severe allergies (I stop breathing) I try to retain what I have once I know I can tolerate it. Very grateful for this article, as it answered my questions and then some.
SAA
I am currently taking Metoprolol Succinate Extended-release Tablets 50 mg once a day. I do not feel I am having any problems; however, I am concerned about the recall and do not know if I am affected.
My medication is in the original bottle which lists the following information:
NDC 49884-405-01
Mfd. by: AstraZeneca AB
S-151 85 Sodertalje, Sweden
Mfd. for: Par Pharmaceutical Cos., Inc.
Spring Valley, NY 10977 U.S.A
Product of India
PAR R12/10
Pharmaceutical LA405-01-69-03
Can you help me determine this$
Marjorie g
I too, had Cardiac problems after being on Metoprolol for a few years. My GP refused to believe I had problems from the medication. Eventually I was hospitalized. The Cardiologist stated that If I had not come to the hospital via 911, I would not have “awaken”. RN.,BA.
Lee
How does that pertain to this conversation? You don’t even tell us if you were on the brand name or the generic or if there was a change.
TLP
Metoprolol tartrate (generic for Lopressor) is not the same drug as the one they are talking about above, which is metoprolol succinate (generic for Toprol XL). Both are metoprolol, but one is long-acting (Toprol XL) and one is not (Lopressor).
Lee
More bad information. Metoprolol Succinate is Toprol. Metoprolol Tartrate is NOT sold under the Toprol name at all.
Metoprolol Succinate = Toprol
Metoprolol Succinate ER = Toprol XL
Metoprolol Tartrate = Lopressor
AnnieT
Thank you for this article,
For a long time I have questioned the effectiveness of generics, particularly those from other countries.
I too have had similar issues with Blood pressure management suffering real lows and real highs along with dizziness at times.
Early on I started on Toprol XL then like all the others was steered into the generic Metoprolol succinate approved by cardiologist..
I cannot begin to comprehend the how and why this country has allowed the importing of the majority of its drugs from countries that do not have the same standards as we once had. Oh I do $$$ but why do we allow it to continue?
Every single day I receive FDA recalls and I am shocked at the amount of recalls on major drugs and IV solutions. These are life saving drugs not some insignificant Supplement. Scares me.
What can we do ? Who can we turn to ? How do we demand safety once again
Respectfully, Annie T
Helen
The FDA has been playing games for years with Wockhardt in India. You contacted them in 2007 re: generic metoprolol and this is 2014 ! If the readers get on their computers and read all the FDA warning letters, import bans etc etc they will be shocked. A general search on Wockhardt problems will result in many many articles regarding all the problems, and yet we continue to let their generics come into this country. Between some doctors not admitting that there are problems with some generics, and the FDA not cracking down hard enough on some of these companies, it is just a losing battle for the patient.
Everyone can look up their pills on drugs.com. There is a pill identifier that allows one to put the code, shape, and color of medications to find out exactly what it is and who manufactured it. Take the time to find out what it is in that bottle that the pharmacy gave you. People who don’t have computers can ask someone to do it for them. It’s important.
Sharon B.
I have taken metoprolol for more than two years with no side effects.
SN
My experience with generic metoprolol was troubling. My doctor prescribed 50 mg Toprol XL for PVCs but my insurance would only cover the generic metoprolol. At the time (2009-2010) the companies making the generic were Watson Labs and Par Pharmaceuticals. My first 3 months were with the Watson version and the PVCs were greatly reduced but I felt slightly lightheaded and seasick. After 90 days I refilled my Rx and got the generic from Par.
BIG difference! I felt much worse: dizzy, off-balance, loads of PVCs – just plain awful. I called around to different pharmacies and checked to see if they used Watson or Par for their generic metoprolol before placing my next order and picking it up. This went on for a year, until I got new insurance and they covered the brand name Toprol XL at an *almost* reasonable cost.
I happily paid the extra because while on the brand name drug I felt human again. No PVCs, much less dizziness, no seasickness. Unfortunately, the Toprol stopped working after a year and I had an ablation. All is well now and I’m drug-free but it scares me to think of all the patients who rely on this drug to control their symptoms and are forced by their insurance company to get the generic.
I know from my personal experience that the generic metoprolol (from any company) just plain doesn’t work as well as the brand name.
Lee
Here again, unless your generic had ER on the name, you were put on the non time-release version. There are TWO different metoprolols….one is time release, one is not. Toprol XL is, and you need the corresponding generic when you switch.
Gerald
After having a bad reaction to a generic toprol in 2007, I began using the AstraZeneca original and then switched to the PAR extended release generic, which is the one authorized by AstraZeneca. It’s more expensive than other generics but I’ve always done well with it (50mg/day), so for me it’s well worth the money (it’s also the only med I take). To my knowledge there’s never been an issue with this generic, but I look forward to PP corroborating that.
VL
I am so glad I read your comments. I also am having a problem with irregular palpitations (very strong) and also since I take my blood pressure every day (As per my cardiologist). I have noticed that it is much higher that it has ever been. I take metoprolol Succ ER 25 Mg at night and metoprolol Succ ER 50 mg in the morning. The 50 Mg. is made in India: company is MYLAN and the 25 mg. metoprolol is made by Par Pharmaceutical.
I had an aortic valve replaced on Oct 28, 2011 and I am 80 years old. I try to be active but the pounding of my heart quickly scares me and I rest until it goes away. Thank you, Mrs. V. Lopez
nese
Thank God for People’s Pharmacy!!!
joe h
I continue to have problems with generic bupropion, it doesn’t seem to have the same release all the time if feel on some days like being on a roller coaster. No way will my insurance pay for name brand and I can’t afford to pay top dollar for it.
Penny H.
My previous internist had me on metoprolol and Lisinopril for high blood pressure. He retired and I asked my new doctor if I needed both since my BP was always in the low normal range. She told me to stop the metoprolol. I did and my BP has actually dropped to an average of 98/60.
paulbyr
What remedies do knowledgeable people suggest? I doubt there is a data gathering organization to record when people die because the drug they needed has vanished and been replace with a non-effective [Indian?] substitute.
ET
This may help someone. Usually, the metoprolol was a small white tapered pill. My prescription was refilled with one that was white and asprin shaped. I only took a couple to experience an irregular heartbeat.
I call the pharmacist and she exchanged the round pills. The problem stopped. I told my previous doctor what had happened and she said, “That couldn’t happen.” I said, “The pharmacist said it could.” Later my drug store was out of the small white tapered shaped pill. I was sent to another drug store to get it refilled. I told the pharmacist what had happened and he said, “Of course, that happened, the round pill is not timed release.”
Comment: When this pharmacist saw my retired military ID card, he paid for the prescription with the comment, “Thanks for your service to our country, my parents were Holocaust victims.”
Another recent change that seems to be OK is the Micardis HCT has been changed to a generic: Telmisartan and Hydrochlorothiazide Tablets USP.
Thanks
SEH
I just picked up a renewal of my generic Metroprolol succinate ER 50 mg from pharmacy. It is generic made by PAR Pharm. Has this manufacturer had any issues with this drug?
thanks
Jackie L.
I have been using metoprolol for several years and have been having ongoing problems with blood pressure spiking for no apparent reason, irregular heart beat which is why I am taking this medicine and it doesn’t seem to be doing much good.
As a result I am now also taking another blood pressure medicine called Micardis. I never really had high blood pressure and only started on medicine because of the irregular heart beat. Metoprolol slows your heart beat and really makes me very listless. Am not happy and am contacting my doctor today.
Carla ARNP
My patients and I thank you for all the great work you do at the People’s Pharmacy! I love that you stay on the FDA trying to make our medications safer. I also appreciate all the non-pharmacological remedies you suggest.
It’s wonderful to have alternatives to offer my low income and under-insured patients.
Craig Donovan
It strikes me that many of the patients who have commented on the poor therapeutic effects of generic medications were at first on a branded pharmaceuticals. With all of the cost management going on in medicine today, I have to believe most patients are started on a generic version when one is available and in that case would never know the difference between an effective and ineffective response. Scary thought.
J.Johnson
In January of 2013 I was admitted to the hospital with a-fib. They tried all sorts of meds on me and even did a cardioversion which did not hold. I continued to have the a-fib but was able to function pretty well on Rythmal, Warfarin and Lisinopril. In an attempt to stop the a-fib my cardiologist put me on Metoprolol Tartrate. I don’t know if this is a similar drug to what you are discussing.
All I know is that within a few hours of the first dose I could not walk across my house without being short of breath and exhausted. And, the a-fib was worse. I was simply unable to function at all. It took me a couple of days to figure out that it was the Metropolol so I stopped it and went back to the original meds.
Finally I was put on Amiodarone and another cardioversion was done which held this time. I was able to drop the dose of Amiodarone from 400 a day to 200 and then to 100 a day. My pulse stays in the 60s and 70s usually and I’m able to finally get back to my normal activities which means walking several miles a week.
I have thought all along that my reaction to Metoprolol was because I’ve been unable to take any beta blocker. Now, I see this on your site and will certainly bring it to the attention of my cardiologist. Of course I am concerned about the many reported side effects of Amiodarone and my eye doctor is watching my eyes carefully for signs of amiodarone in the cornea. I did notice at once that it caused muscle aches and a phlegm producing cough, but, it allows me to function without a-fib. I’m 78 years old anyway. I figure the good outweighs the bad.
M. Wood
I used the generic, metoprolol Succ and had the same result as tho I’d had food poisoning.
I was switched to TOPROL XL (non-generic)with the dosage cut back 50%. It worked. This is strong stuff. I think doctor’s should start small and if needed, then work up to a stronger dosage.
Lee
Was your generic timed release or not? That’s the important piece.
Tom P
How do I know if the pills I have are good/bad/recalled? My blood pressure is good but I’ve been experiencing some numbness and headaches lately?
NGA
I have supraventricular tachycardia proximal and have been taking Metoprolol Tartrate ONLY when I need it for palpitations which happen about once or twice per month. I am very concerned, although I have not had any problems with my drug other than it sometimes takes longer to work.
I was notified just this morning (e-mail) by Walgreen’s that they cannot refill my prescription. It is gratifying that they are on top of things!
I was not aware that my medication was being produced in India. Had I known, I would have requested a change.